in this investigation, diabetes was induced in adult male sprague-dawley rats by single intraperitoneal injection of streptozotocin (stz) at 45 mg kg-1 of body weight. a group comprised of 8 diabetic rats was treated with metformin at 100 mg kg-1 of body weight for reducing the elevated blood glucose level. the results revealed that, in the untreated diabetic rats, the body and testicular weigh...

introduction: diabetes mellitus impairs the metabolism of carbohydrates, lipids and proteins, which leads to the dysfunction of the central and peripheral nervous system. this study evaluates the effects of an aloe vera hydro-alcoholic extract on diabetic neuropathy. materials and methods: for this study, 48 healthy male sprague dawley rats(weighed 250-200 g) were randomly divided in to three g...

abstract  introduction: diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. this study was designed to investigate the effect of trigonella foenum-graecum (tfg) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (stz)-induced diabetic rats.  methods:...

background and objective: in this research, the effect of chronic dietary soybean aqueous extract on aortic reactivity of streptozotocin (stz)-diabetic rats was investigated. materials and methods: stz-diabetic rats were treated with soybean aqueous extract for two months after diabetes induction. contractile reactivity to kcl and phenylephrine (pe) and relaxation response to acetylcholine (ach...

background: this study examined the effect of grape seed proanthocyanidin extract (gspe) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. methods: thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg gspe for 6 w...

background: hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. the present study was designed to determine the role of gamma amino butyric acid b (gabab) receptor and l-arginine (l-arg) in gaba-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. methods: diabetes was induced by a single i.p. injection of strepto...

introduction: hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of patients. considering the evidence on the antidiabetic and analgesic effects of nigella sativa (ns), this study was designed to investigate the analgesic effects of ns on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (stz)-induc...

background: diabetes is one of the most common metabolic disorders and is related to oxidative-stress-induced diseases. given the role of dietary antioxidants in the control and prevention of diabetes, this study aimed to examine the effects of sesame butter versus sesame oil on the serum levels of glucose, lipid profile, and oxidative stress biomarkers in diabetic rats. methods: forty male alb...

introduction: hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. this study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (stz)-diabetic rats using formalin and hot tail immersion tests. methods: rats were divided into control, control or diabetic ...

angiotensin-converting enzyme (ace) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. the present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (stz)-diabetic rats treated for 4 weeks with nitro-l-arginine-methyl ester (l-nam...