Ionizing radiation induces delayed genomic instability in human cells, including chromosomal abnormalities and hyperrecombination. Here, we investigate delayed genome instability of cells exposed to UV radiation. We examined homologous recombination-mediated reactivation of a green fluorescent protein (GFP) gene in p53-proficient human cells. We observed an approximately 5-fold enhancement of d...

Drug hypersensitivity reactions (DHR) have potential for significant morbidity and mortality, without clear treatment severe reactions. Standard of care is to immediately stop culprit drug(s) never rechallenge. However, the drug and/or whether patient would develop a form DHR unknown. Even if reaction severe, may no alternative their underlying disease. Analysis bulk transcriptional profiling s...

In conformally invariant quantum field theories one encounters besides the standard DHR superselection theory based on spacelike (Einstein-causal) commutation relations and their Haag duality another timelike (”Huygens”) based superselection structure. Whereas the DHR theory based on spacelike causality of observables confirmed the Lagrangian internal symmetry picture on the level of the physic...

Brain metabolites and arterial acid-base measurements were made one hr after bilateral carotid artery occlusion in 2 different models of hypertensive rats. Animals used included renovascular hypertensive rats (RHR) with an altered renin-angiotensin system and desoxycorticosterone hypertensive rats (DHR) with low plasma renin activity (PRA). The mean value for supratentorial lactate of 7.41 mM/k...

In conformally invariant quantum field theories one encounters besides the standard DHR superselection theory based on spacelike (Einsteincausal) commutation relations and their Haag duality another timelike (”Huygens”) based superselection structure. Whereas the DHR theory based on spacelike causality of observables confirmed the Lagrangian internal symmetry picture on the level of the physica...

The conventional wisdom is that switching costs raise prices and make markets less competitive. Dube, Hitsch and Rossi (2009, hereafter DHR) demonstrate a U shaped relationship between switching costs and equilibrium average prices; i.e., prices fall at low levels of switching costs and then rise as switching costs become very high. DHR show this result using a numerical solution of an infinite...

We consider the problem of sampling a point from an arbitrary distribution π over an arbitrary subset S of an integer hyper-rectangle. Neither the distribution π nor the support set S are assumed to be available as explicit mathematical equations but may only be defined through oracles and in particular computer programs. This problem commonly occurs in black-box discrete optimization as well a...

T-1-rho (T1ρ) magnetic resonance imaging (MRI) and disc height ratio (DHR) are potential biomarkers of degenerative disk disease (DDD) related to biochemical composition and morphology of the intervertebral disk (IVD), respectively. To objectively detect DDD at an early stage, the hypothesis was tested that the average T1ρ relaxation time of the nucleus pulposus (NP) correlates with the disk he...

OBJECTIVE There is literature examining the total number of procedures performed by surgery residents before and after duty hour restrictions (DHR). There is insufficient literature addressing the effect of DHR on the number of procedures in which residents directly participate as an assistant, rather than as the primary operating surgeon. METHODS The operative experience of general surgery r...

We used a murine mAb, H4/18, raised by immunization with IL-1-treated human umbilical vein endothelial cell cultures, to localize an endothelial activation antigen in induced human delayed hypersensitivity reactions (DHR) and in pathological tissues. We used streptococcus varidase to elicit DHR in human skin and we examined sequential skin biopsies with the immunoperoxidase technique. There was...