Haematological toxicities and thromboembolic (TE) events are common complications of myeloma therapy. TE risk may be elevated with combination regimens, notably thalidomide/lenalidomide plus high-dose dexamethasone; concomitant erythropoietin appears to further increase the risk with lenalidomide-dexamethasone. We characterised thrombocytopenia and neutropenia in the phase 3 APEX (Assessment of...

  Introduction: Adequate pain control is an important consideration in the post-surgical management of patients. Local nerve blockade added to general anesthesia can provide excellent pain control during and after most nasal surgical procedures. The aim of this study was to determine the combined effect of local anesthetic drugs with corticosteroids in nasal surgery. Materials and Methods: In t...

Background: Intussusception is one of the most commonly encountered abdominal emergencies in children for which preferred treatment modality has always been non operative hydrostatic reduction. Recurrence a common concern after successful Adjuvant with pharmacological agents have considered to reduce chances recurrence. Aim: The study was conducted examine role dexamethasone decreasing early re...

BACKGROUND AND OBJECTIVES Perineural dexamethasone prolongs the duration of single-injection peripheral nerve block when added to the local anesthetic solution. Postulated systemic mechanisms of action along with theoretical safety concerns have prompted the investigation of intravenous dexamethasone as an alternative, with decidedly mixed results. We aimed to confirm that addition of intraveno...

Postoperative nausea and vomiting is an unpleasant, distressing, and exhausting experience for patient. This is more common and severe in tympanomastoid surgery. The role of dexamethasone prevention of this complication is unclear and during recent years much attention has been paid to it. In order to evaluate prophylactic effect of dexamethasone on postoperative nausea and vomiting after masto...

AIM To evaluate the efficacy of intravitreal dexamethasone injections in diabetic macular edema (DME). METHODS A 700 μg slow-release intravitreal dexamethasone implant (Ozurdex®) was placed in the vitreal cavity of 17 patients (19 eyes) affected with persistent DME. Best corrected visual acuity (BCVA) was assessed through Early Treatment Diabetic Retinopathy Study (ETDRS). Central macular thi...

The importance of dexamethasone is demonstrated by its wide uses in human and veterinary medical practices [14]. Clinically, dexamethasone is administered to animals for the treatment of disease conditions such canine distemper, meningitis, necrotizing enterocolitis [5-10]. In humans, dexamethasone is most notably, used for the treatment of various complications, such as preterm complications t...

Diabetic macular edema (DME) resembles a chronic, low-grade inflammatory reaction, and is characterized by blood-retinal barrier (BRB) breakdown and retinal capillary leakage. Corticosteroids are of therapeutic benefit because of their anti-inflammatory, antiangiogenic, and BRB-stabilizing properties. Delivery modes include periocular and intravitreal (via pars plana) injection. To offset the s...

Routine use of steroids in the treatment of bacterial meningitis remains controversial. A prospective placebo controlled double blind study of dexamethasone was carried out in 40 patients (age>10 years) of acute bacterial meningitis. The patients were randomly assigned to receive either placebo (n=20) or dexamethasone (n=20) in addition to injection ceftriaxone 100 mg/kg/day (maximum 4 gm/day) ...