dermcidin

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, with increasing prevalence affecting millions of people worldwide. Currently, only autopsy is able to confirm the diagnosis with a 100% certainty, therefore, biomarkers from body fluids obtained by non-invasive means provide an attractive alternative for the diagnosis of Alzheimer`s disease. Global changes of the pro...

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Folding and Self-Assembly of the TatA Translocation Pore Based on a Charge Zipper Mechanism

Journal: :Cell 2013

Torsten H. Walther Christina Gottselig Stephan L. Grage Moritz Wolf Attilio V. Vargiu Marco J. Klein Stefanie Vollmer Sebastian Prock Mareike Hartmann Sergiy Afonin Eva Stockwald Hartmut Heinzmann Olga V. Nolandt Wolfgang Wenzel Paolo Ruggerone Anne S. Ulrich

We propose a concept for the folding and self-assembly of the pore-forming TatA complex from the Twin-arginine translocase and of other membrane proteins based on electrostatic "charge zippers." Each subunit of TatA consists of a transmembrane segment, an amphiphilic helix (APH), and a C-terminal densely charged region (DCR). The sequence of charges in the DCR is complementary to the charge pat...

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