We have examined the efficacy of the administration in mice of a molecularly defined vaccine based on the Leishmania infantum acidic ribosomal protein P0 (rLiP0). Two different challenge models of murine cutaneous leishmaniasis were used: (i) subcutaneous inoculation of L. major parasites in susceptible BALB/c mice (a model widely used for vaccination analysis) and (ii) the intradermal inoculat...

BACKGROUND Eczema vaccinatum is a life-threatening complication of smallpox vaccination in patients with atopic dermatitis (AD) characterized by dissemination of vaccinia virus (VV) in the skin and internal organs. Mutations in the filaggrin (FLG) gene, the most common genetic risk factor for AD, confer a greater risk for eczema herpeticum in patients with AD, suggesting that it impairs the res...

objective: objective: dermal papilla and hair epithelial stem cells regulate hair formation and growth cycle. damage to or losing of these cells can cause hair loss. although several studies have claimed to reconstitute hairs using rodent cells in animal model, a stable human hair follicle reconstitution protocol needs more studies. here in this study we evaluated hair induction through injecti...

closure of fascia after transverse rectus abdominis musculocutaneous (tram) flap has usually been performed with direct closure or synthetic material. the dermal autograft was removed from zone iv of flap was an alternative to reinforce fascial closure. the dermal autograft was used in 34 patients after tram harvest for breast, head and neck reconstruction and prolene mesh was used in 42 other ...

Control of Leishmania Major Infection in a Mouse Model of Cutaneous Leishmaniasis A murine model of cutaneous leishmaniasis, using needle inoculation of Leishmania major, represents perhaps the most widely used system to study the contrasting effects of Th1 versus Th2 immunity in disease control. One of the intriguing aspects of this disease model is that certain strains of mice, such as BALB/c...

in this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. the effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

objective(s): with the advent of nanotechnology, significant progress has been made in the area of nanoscale materials such as nanosilver (ag-nps). these nanoparticles have a wide range of applications and been used for antimicrobial purposes for more than a century. however, little attention has been paid to the toxicity of nanosilver wound dressing. this study was designed to investigate the ...

background we present a novel method for augmenting the standard c-v flap used for nipple reconstruction with a free dermal graft which aims to improve the appearance of the nipple reconstruction, decrease loss of projection and improve patient satisfaction overall. methods the surgical technique for performing a free dermal graft augmentation of a cv flap is described. all patients who underwe...