In Multi-Echelon Vehicle Routing Problems the delivery from one or more depots to the customers is managed by routing and consolidating the freight through intermediate depots, called satellites. This family of problems differs from Multi-Echelon Distribution Systems present in the literature. In the latter the attention is focused on the flow assignment among the levels only, while we also con...

We study the Multi-Depot Multiple Traveling Salesman Problem (MDMTSP), which is a variant of the very well-known Traveling Salesman Problem (TSP). In the MDMTSP an unlimited number of salesmen have to visit a set of customers using routes that can be based on a subset of available depots. The MDMTSP is an NPhard problem because it includes the TSP as a particular case when there is only one dep...

This study aimed to develop an optimized depot injectable atorvastatin (ATR) biodegradable in situ gel (ISG) system with minimum initial burst using a central composite design. The factors selected were poly (d, l-lactide-co-glycolide) (PLGA) concentration (X1), molecular weight of polyethylene glycol (PEG) (X2), and PEG concentration (X3). The independent variables were the initial burst of AT...

OVERVIEW OF OLDER AND NEWER AGENTS Schizophrenia, with its accompanying signs and symptoms of delusions, hallucinations, disorganized thoughts, inappropriate affect, and impaired psychosocial functioning, is considered one of the more complex psychiatric disorders to treat.1 One reason for this difficulty is the tendency for patient noncompliance with medication regimens. This trend of nonadher...

in this paper, we study the multi-depot vehiclerouting problem with inter-depot routes, in which the vehicles can replenish atintermediate depots. vehicles leave the origin depot with load on-board andserve customers until out of load. they may visit an intermediate depot toreplenish and finally return to the origin depot, completing their route. weinitiate a mathematical mixed integer programm...

The depot formulation of liposomal cytarabine (DepoCyte) has proven to be useful as intrathecal (IT) treatment of neoplastic and lymphomatous meningitis. We report the results of compassionate use of DepoCyte in 6 patients diagnosed with acute leukemia (AL) and CNS involvement. Two patients had CNS involvement at diagnosis and the remaining 4 had CNS relapse. Three patients received DepoCyte as...

Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local injection of heparin before a spinal cord injury reduces cell proliferation and astrogliogenesis associated with...

BACKGROUND Depot medroxyprogesterone acetate is the most studied injectable contraceptive and also one of the most effective methods of contraception currently available. It is reversible, its use is independent of intercourse, and can be provided by trained non-medical staff making it particularly suitable for use in developing countries. The aim of this study is to determine the socio-demogra...

This paper studies an unmanned aerial vehicle (UAV)-assisted wireless network, where a UAV is dispatched to gather information from ground sensor nodes (SN) and transfer the collected data depot. The freshness captured by age of (AoI) metric, whilst energy consumption seen as another performance criterion. Most importantly, AoI efficiency are inherently competing metrics, since decreasing requi...