Elevated cholesteryl ester transfer protein-mediated transfer of cholesteryl ester (CE) from high-density lipoprotein (HDL) to low-density lipoprotein (LDL) may contribute to the atherogenicity of LDL in subjects with familial hypercholesterolemia (FH). To identify the major CE acceptors among LDL subspecies, we investigated the qualitative and quantitative features of CE transfer and exchange ...

Objective(s): Hypercholesterolemia is a common metabolic disorder in developing and developed countries and is associated with the increased rates of chronic kidney disease (CKD). Statin therapy could reduce cholesterol synthesis as well as progression of CKD. Diversity between statins causes variety in pharmacokinetics and pharmacodynamics and also their pleiotropic e...

oxidation of low density lipoprotein (ldl) has been strongly implicated in the phathogenesis of atherosclerosis. the use of oxidants in dietary food stuff may lead to the production of oxidized ldl and may increase both the development and the progression of atherosclerosis. the present work investigated the effects of some elements including: copper (cu), iron (fe), vanadium (v) and titanium (...

familial hypercholesterolemia (fh) is an autosomal co-dominant disorder of lipid metabolism, caused by mutations in ldl receptor gene. the penetrance of fh is almost 100%, meaning that half of the offspring of affected parents born with disease. the patients are at risk of premature coronary heart disease (chd). there is no report about the molecular basis of fh in iran. identification of mutat...

Limitations in our ability to predict cardiovascular risk have fueled efforts to identify novel risk markers and to refine the measurement of traditional risk factors, such as low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). Standard assays to evaluate LDL-C and HDL-C quantify the cholesterol content within the respective lipoprotein fraction. Howeve...

Oxidation of low density lipoprotein (LDL) by cells of the arterial wall or in the presence of copper ions was shown to result in the peroxidation of its fatty acids as well as its cholesterol moiety. LDL incubation with cholesterol oxidase (CO) resulted in the conversion of up to 85% of the lipoprotein unesterified cholesterol (cholest-5-en-3-ol) to cholestenone (cholest-4-en-3-one) in a dose-...

This thesis is based on the following original articles, which are referred to in the text by their Roman numerals. acid content of LDL and lipoprotein metabolism in combined hyperlipidemia and primary moderate hypercholesterolemia. acid content of LDL and its relation to lipid concentrations and metabolism of LDL and cholesterol. Submitted. increases the sialic acid content of LDL in hyperchol...

background: the present study was undertaken to estimate and compare the levels of plasma total cholesterol (tc), low density lipoprotein (ldl), high density lipoprotein (hdl), very low density lipoprotein (vldl) and triglycerides in patients with oral precancerous lesions/conditions, oral cancer and normal subjects. materials and methods: the study comprised of 60 patients with oral precancero...

The association of plasma low density lipoproteins (LDL) with arterial proteoglycans (PG) is of key importance in LDL retention and modification in the artery wall. Lipoprotein lipase (LpL), the rate-limiting enzyme for hydrolysis of lipoprotein triglyceride, is known to bind both LDL and arterial PG. In the presence of LpL, cellular internalization and degradation of LDL is enhanced by a pathw...