Restless legs syndrome is common in patients with multiple sclerosis but has not been reported as occurring due to an acute, inflammatory, demyelinating attack. Restless legs syndrome is known to be related to low brain iron levels. Multiple sclerosis has been associated with the abnormal accumulation of iron in the chronic, progressive phase of axonal degeneration. Iron deficiency may play a r...

The purpose of this scientometric study is to analyze the multiple sclerosis research in Science Citation Index-Expanded from 1992 to 2019 in order to determine the top features, trends, and topics. Articles related to multiple sclerosis in the section of title, abstract, keywords, and KeyWords Plus were retrieved from the Science Citation Index-Expanded and analyzed based on various indicators...

Background: Bone marrow mesenchymal stem cells (BM-MSCs) elicit neuroprotective effects, and their repair ability has been investigated in different experimental models. We aimed to investigate the effect of multiple i.p. BM-MSCs injections in the cuprizone model of multiple sclerosis in mice. Methods: Adult male C57BL/6 mice (n = 40) were fed a regular diet or a diet containing cuprizone (0.2%...

We investigated the frequency of oval-shaped, high-signal-intensity lesions oriented perpendicular to the anteroposterior axis of the brain on abnormal, axial T2-weighted MR brain scans in 59 patients with clinically documented multiple sclerosis. This finding, not heretofore described in patients with multiple sclerosis, was observed in 86% of patients, and correlates with the neuropathologic ...

mulTiple sClerosis In multiple sclerosis, autoreactive T cells cross the blood-brain barrier under the influence of proinflammatory cytokines and cellular adhesion molecules, resulting in an attack on myelin, with resulting inflammation, degeneration and demyelination. Given the multitude of interactions involved in the immunopathogenesis of multiple sclerosis, several immunological pathways ma...

Multiple sclerosis, a chronic inflammatory disease of the CNS, is characterized by immune-mediated demyelination. Many patients have a remitting-relapsing course of disease with exacerbations often following unrelated microbial illnesses. The relationship between the two events remains obscure. One possibility is that T cells specific for the inciting microbial pathogen are able to effect demye...

There are few case reports documenting a new onset of demyelinating processes in patients receiving anti-tumour necrosis factor alpha therapy (anti-TNF alpha) for chronic inflammatory arthropathies. Whether anti-TNF alpha therapy induces new onset demyelination or just exacerbates pre-existing latent multiple sclerosis is not fully understood. We are reporting a 51-year-old woman without a prio...

Despite a century of intensive investigation, the underlying cause of multiple sclerosis has eluded us. It is clear that there exists a prominent progressive degenerative phenotype together with an important autoimmune inflammatory component, and careful histopathological examination always shows, to a greater or lesser degree, concomitant degeneration/demyelination and adaptive T cell-dependen...

Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. Materials and Methods: Adult male C57BL/6J mice were fed a chow containing 0.2 % cuprizone for 6 ...

Oligodendrocyte loss and demyelination are major pathological hallmarks of multiple sclerosis. In pattern III lesions, inflammation is minor in the early stages, and oligodendrocyte apoptosis prevails, which appears to be mediated at least in part through mitochondrial injury. Here, we demonstrate poly(ADP-ribose) polymerase activation and apoptosis inducing factor nuclear translocation within ...