OBJECTIVE Caspase-8 (CASP8) plays a central role in the apoptotic pathway and aberrant regulation of this pathway may cause cancers. Previous studies investigating the association between CASP8 -652 6N ins/del polymorphism and colorectal cancer (CRC) risk showed inconclusive results. We performed a meta-analysis of all available studies to investigate this association. METHODS All studies pub...

the existence of eight imitations and five translations of hosn va del into other languages such as english and german shows the importance of this persian book of verse. many researchers have sought the sources of this work and some sources have been mentioned, but the imitation of sibak neishaburi from nezami’s khosrow va shirin, as the most important source of this work, has not yet been m...

The clinical and hematological characteristics and the prognostic significance of del(20q) were investigated in a consecutive series of 213 myeloid malignancies. In the analyses, the cases were divided into three subgroups according to diagnosis or four subgroups according to cytogenetic data. Patients in the myeloproliferative neoplasms subgroup had high WBCs and platelet counts at initial dia...

conclusions our findings indicated that mdm2 40-bp ins/del polymorphism was not associated with all in our iranian population. further studies with larger sample sizes and diverse ethnicities are required to verify our findings. background the human murine double minute 2 (mdm2), an oncoprotein, is the major negative regulator of p53. objectives the purpose of this study was to evaluate the imp...

CpG island aberrant methylation is shown to be an important mechanism in gene silencing. The important role of NF-κB in the inflammatory response to H. pylori colonization has been indicated. We investigated the influence of NFKB1 polymorphisms, -94 ins/del (rs28362491) and -449 C>G (rs72696119), on the aberrant gene methylation under H. pylori infection. Gastric mucosal samples were obtained f...

BACKGROUND MDM2 (Murine Double Minute2) is an oncoprotein that inhibits the P53 activity. Overexpression of MDM2 gene has been reported in several human tumors. In the present study, we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism on the promoter of MDM2 and susceptibility to breast cancer in a sample of Iranian population. METHODS This case-control study wa...

Sr. Editor. Del 28 al 30 de abril de 2014 se llevó a cabo en Lima una reunión de expertos para presentar las investigaciones que se desarrollan en Perú sobre contaminación del aire, contaminación del agua y el impacto del cambio climático/variabilidad climática y su impacto en salud y las prioridades de investigación que se pueden establecer en la actualidad. En este taller participaron investi...

BACKGROUND Developmentally regulated endothelial locus-1 (Del-1) is an extracellular matrix protein that is expressed by endothelial cells during embryological vascular development. We speculated that Del-1 may be reexpressed in ischemia and may be involved in endogenous angiogenesis. METHODS AND RESULTS Del-1 protein was detected by immunohistochemistry in murine ischemic hindlimb after femo...

RESOLUCIÓ de 14 de febrer de 2018, del president de l’Institut Valencià de Competitivitat Empresarial (IVACE), per la qual es convoquen subvencions per a la preparació de propostes per a la presentació a convocatòries del Programa Marc d’Investigació i Innovació 2014 2020 Horitzó 2020 (Horitzó-CV), a càrrec del pressupost de l’exercici 2018. [2018/1942] RESOLUCIÓN de 14 de febrero de 2018, del ...