If you have chronic back or neck pain, you may have degenerative disc disease. This degenerative spinal condition is not really a disease—it’s the normal wear and tear process of aging on your spine. Unfortunately, as we age, our intervertebral discs (pillow-like pads between the bones in your spine) lose their flexibility, elasticity, and shock absorbing characteristics. When this happens, the...

Objective: Our objective is to analyse the clinical effect and safety of Polyetheretherketone (PEEK) cage for lumbar fusion and the pedicle screw-based internal fixation in senile lumbar degenerative diseases, and further discuss the value of clinical application. Methods: 172 patients with senile lumber degenerative diseases admitted in our hospital during March, 2013-March, 2016 were selected...

Although success has been achieved with implantation of bone marrow mesenchymal stem cells (bMSCs) in degenerative discs, its full potential may not be achieved if the harsh environment of the degenerative disc remains. Axial distraction has been shown to increase hydration and nutrition. Combining both therapies may have a synergistic effect in reversing degenerative disc disease. In order to ...

Pain and lifestyle changes are common consequences of intervertebral disc degeneration (IVDD) affect a large part the aging population. The stemness cells is exploited in field regenerative medicine as key to treat degenerative diseases. Transplanted however often face delivery survival challenges, especially tissues with naturally harsh microniche environment such disc. Recent interest secreto...

Painful degenerative disc diseases have been targeted by different biological treatment approaches. Nucleus pulposus (NP) cells play a central role in intervertebral disc (IVD) maintenance by orchestrating catabolic, anabolic and inflammatory factors that affect the extracellular matrix. IVD degeneration is associated with imbalances of these factors, resulting in a catabolic inflammatory metab...