Introduction: Bleomycins are DNA-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as Yb-175. In this work the development of Yb-175 bleomycin (175Yb-BLM) has been reported. Methods: Yb-175 chloride was obtained by thermal neutron irradiation (3 × 1013 n.cm-2.s-1) of natural Yb2O<...

Background: Conflicting studies link several conditions and risk factors to Dupuytren’s disease (DD). A questionnaire-based case-control study was set to investigate associated conditions and clinical features of DD in a sample of Italian patients. The main purpose was the identification of predicting factors for: DD development; involvement of multiple rays; involvement of both hands; developm...

This paper summarizes recent results on non-SUSY searches at the Fermilab Teva-tron p p collider. All the analysis are based on the complete data samples recorded by both the CDF and DD collaborations during the 1992-1995 running period (Run I), and correspond to 100 pb ?1. Searches for new neutral heavy vector bosons, leptoquarks, dijet mass resonances, and associated production of new heavy s...

Abstract High sensitizer and activator concentrations have been increasingly examined to improve the performance of multi-color emissive upconversion (UC) nanocrystals (UCNC) like NaYF 4 :Yb,Er first strategies were reported reduce concentration quenching in highly doped UCNC. UC luminescence (UCL) is, however, controlled not only by dopant concentration, yet an interplay different parameters i...

Regulated gene expression is essential for a proper progression through the cell cycle. The transcription factor NF-Y has a fundamental function in transcriptional regulation of cell cycle genes, particularly of G2/M genes. In order to investigate common and distinct functions of NF-Y subunits in cell cycle regulation, NF-YA, NF-YB and NF-YC have been silenced by shRNAs in HCT116 cells. NF-YA l...

Antigen-specific, major histocompatability complexrestricted recognition by classical T cells is mediated by a T cell receptor (TCR) consisting of a disulfidelinked aj3 heterodimer. During the search for the genes encoding the a and /3 proteins, a third immunoglobulinlikegene, termed y, was uncovered. Like the 7CR a and /3genes, the TCR -ygene consistsof variable and constant segments that rear...

Death-associated protein kinase (DAPk) is a calcium/calmodulin-regulated Ser/Thr-protein kinase that functions at an important point of integration for cell death signaling pathways. DAPk has a structurally unique multi-domain architecture, including a C-terminally positioned death domain (DD) that is a positive regulator of DAPk activity. In this study, recombinant DAPk-DD was observed to aggr...

Background: Dentin dysplasia (DD) is a rare disturbance of dentin formation, characterized by normal enamel but atypical dentin formation with abnormal pulpal morphology. In DD type I, the teeth appear clinically normal in morphologic appearance and color. Radiographic analysis shows obliteration of all pulp chambers as well as short, blunted, and malformed or absent roots with multiple periapi...

AKI is associatedwith a rapiddecline in renal function andhigh mortality rates. Furthermore patients that survive an acute illness have a high risk of developing ESRD from concomitant or aggravated CKD.1 Ischemia and reperfusion injury (IRI) is a leading cause of AKI. In the ischemic kidney decreased delivery of oxygen and nutrients results in tissue hypoxia and microvascular dysfunction while ...

Three large macromolecular complexes known as the death-inducing signaling complex (DISC), the apoptosome and the PIDDosome mediate caspase activation in apoptosis signaling pathways. The PIDDosome, which activates caspase-2, is composed of three protein components: PIDD, RAIDD and caspase-2. Within the PIDDosome, the interaction between PIDD and RAIDD is mediated by a homotypic interaction bet...