Introduction Dynamic contrast enhanced MRI (DCE-MRI) is used to characterize perfusion and extracellular volume in tumors through the tracer kinetic modeling of MRI contrast agents (typically Gd-DTPA). However, the parametric estimates resultant of DCE-MRI may be influenced by several confounding factors, including inter-compartmental water exchange [1]. In contrast to MRI contrast agents, radi...

breast cancer continues to be a significant public health problem in the world. early detection is the key for improving breast cancer prognosis. in this way, magnetic resonance imaging (mri) is emerging as a powerful tool for the detection of breast cancer. breast mri presently has two major challenges. first, its specificity is relatively poor, and it detects many false positives (fps). secon...

This meta-analysis assesses the prognostic value of quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI) performed during neoadjuvant therapy (NAT) of locally advanced breast cancer. A systematic literature search was conducted to identify studies of quantitative DCE-MRI and DW-MRI performed during breast cancer NAT that report the sens...

parameters evaluated from black blood DCE-MRI and histological bio-markers. Table 1. ICCs of the three parameters evaluated from black blood DCE-MRI. Fig 1. An example of the produced V-V image with K in green channel and vp in red channel. The point label the lumen of aorta. The arrow points the adjacent muscle. Assessment of inflammation in a rabbit model of early atherosclerosis: reproducibi...

OBJECTIVE To establish the interobserver reproducibility of tumour volumetry on individual multiparametric (mp) prostate MRI sequences, validate measurements with histology and determine whether functional to morphological volume ratios reflect Gleason score. METHODS 41 males with prostate cancer treated with prostatectomy (Cohort 1) or radical radiotherapy (Cohort 2), who had pre-treatment m...

Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) of the breast is a routinely used imaging method which is highly sensitive for detecting breast malignancy. Specificity, though, remains suboptimal. Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI), an alternative dynamic contrast imaging technique, evaluates perfusion-related parameters unique from DCE MRI. Prev...

Recent progress in imaging technologies leads to a continuous growth in biomedical data, which can provide better insight into important clinical and biological questions. Advanced machine learning techniques, such as artificial neural networks are brought to bear on addressing fundamental medical image computing challenges such as segmentation, classification and reconstruction, required for m...

Rectal tumour segmentation in dynamic contrast-enhanced MRI (DCE-MRI) is a challenging task, and an automated and consistent method would be highly desirable to improve the modelling and prediction of patient outcomes from tissue contrast enhancement characteristics - particularly in routine clinical practice. A framework is developed to automate DCE-MRI tumour segmentation, by introducing: per...

OBJECTIVE To determine whether quantitative perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlate with immunohistochemical markers of angiogenesis in rectal cancer. MATERIALS AND METHODS Preoperative DCE-MRI was performed in 63 patients with rectal adenocarcinoma. Transendothelial volume transfer (K(trans) ) and fractional volume of the extravascular...

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is performed after the administration of intravenous contrast medium to noninvasively access tumor vascular characteristics. DCE-MRI techniques utilizing low-molecular-weight contrast media have successfully made the transition from methodological development to preclinical and clinical validation and are now rapidly becoming mainst...