Li RH, Churchill GA. Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice. Physiol Genomics 42A: 228 –234, 2010. First published September 21, 2010; doi:10.1152/physiolgenomics.00044.2010.—Stressful environmental factors, such as a high-fat diet, can induce responses in the expression of genes that act to maintain physiological homeostasis. We observed variation in p...

Chronic exposure to high glucose leads to diabetic nephropathy characterized by increased mesangial matrix protein (e.g., collagen) accumulation. Altered cell signaling and gene expression accompanied by oxidative stress have been documented. The contribution of the tyrosine kinase, c-Src (Src), which is sensitive to oxidative stress, was examined. Cultured rat mesangial cells were exposed to h...

We have previously shown that long-term in vitro proliferating fetal liver pre-B cell lines derived from autoimmune-prone (NZB x NZW)F1 (BW) mice, but not normal (B6 x DBA2)F1 mice, can differentiate in severe combined immunodeficient (SCID) mice to produce elevated levels of serum immunoglobulin (Ig) M and IgG, and high titers of antinuclear antibodies The contribution of parental NZB and NZW ...

Caspase-11 (Cas11) is a cysteine protease involved in programmed cell death and cytokine maturation. Through activation of Cas1 (interleukin-1beta [IL-1beta]-converting enzyme), Cas11 is directly involved in the maturation of IL-1beta and IL-18. Apoptosis is mediated through Cas3. Given the role of apoptosis and cytokine signaling during the innate immune response in intracellular infection, we...

BACKGROUND We observed that a dim, red light-emitting diode (LED) triggered by activity increased the circadian periods of lab mice compared to constant darkness. It is known that the circadian period of rats increases when vigorous wheel-running triggers full-spectrum lighting; however, spectral sensitivity of photoreceptors in mice suggests little or no response to red light. Thus, we decided...

-We observed the growth of 2 sublines of leukaemia L1210 in histocompatible DBA2 mice given 103 cells i.p. and studied the protective effect of Corynebacterium parvum (CP). The growth of subline 1,1210 -M was unaffected by pretreatment with CP or admixture with 105 peritoneal cells (PC) from CP-treated mice. In contrast, the growth of subline L1210-C was inhibited; CP pretreatment increased the...

Repeated evidence has demonstrated that combined primer-booster immunization regimens can improve both secreted and humoral immune responses to antigens derived from viral, bacterial, and parasitic pathogens. For the present work, we evaluated the synergic serum immunoglobulin G (IgG) and fecal IgA antibody responses elicited in BALB/c mice who were intramuscularly primed with a DNA vaccine, pR...

The following mouse strains were used: C57BL/6 x DBA2 F1 (hereafter called BD2F1), 6 to 10 weeks old (A. R. Schmidt Co., Madison, Wis.), AKR/J, and C57BL/6J (The Jackson Laboratory, Bar Harbor, Maine). All groups con sisted of 5 or 10 male mice. The mouse neoplasms studied were the parental line L1210 and sublines ofLl2lO resistant to methotrexate and 6-methylmercaptopurineriboside; L5178Y and ...

The functional septo-temporal (dorso-ventral) differentiation of the hippocampus is accompanied by gradients of adult hippocampal neurogenesis (AHN) in laboratory rodents. An extensive septal AHN in laboratory mice suggests an emphasis on a relation of AHN to tasks that also depend on the septal hippocampus. Domestication experiments indicate that AHN dynamics along the longitudinal axis are su...