Like the biological clock in the body, replication of each cell type (even different cells of the same organism) follows a timing program. Abnormal function of this timer could be an alarm for a disease like cancer. DNA replication starts from a specific point on the chromosome that is called the origin of replication. In contrast to prokaryotes in which DNA replication starts from a single ...

The ds-RNA activated protein kinase (PKR) is a serine-threonine kinase with MW of 68 KDa. It belongs to a family of kinases that control one of the translational initiation factors, eIF2. PKR is produced at high level in response to viral infection. This protein by phosphorylating eIF2 inhibits cellular protein synthesis. In this study, the effect of gamma interferon (IFN-γ), an activator, and ...

With the evolution of geographically distributed data centers in Cloud Computing landscape along with amount being processed these centers, which is growing at an exponential rate, processing massive applications become important topic. Since a given task may require many datasets for its execution and are spread over several different finding efficient way to manage storage across nodes system...

In a peer-to-peer (p2p) system, a large number of nodes share data with each other. The participation of nodes is highly dynamic; nodes may enter and leave the system at will. Since, it is not possible to maintain links with all nodes, for performance as well as for privacy and anonymity reasons, each node maintains links with a selected subset of other nodes, thus forming an overlay network. A...

Computer grids are collections of heterogeneous computer resources that work together to form a single system. Goal of that system is conducting difficult and data intensive scientific or technological calculations. This is achieved by sharing resources and data among different users and organizations. The special property of a grid system is that not only users, but also the resources are dyna...