Previously, D2 dopamine receptors (D2 DARs) have been shown to undergo G-protein-coupled receptor kinase phosphorylation in an agonist-specific fashion. We have now investigated the ability of the second messenger-activated protein kinases, protein kinase A (PKA) and protein kinase C (PKC), to mediate phosphorylation and desensitization of the D2 DAR. HEK293T cells were transiently transfected ...

BACKGROUND Loss of dorsal acetabular rim (DAR) is a common sequela to canine hip dysplasia. The purpose of this study is to evaluate the effect of DAR loss on the initial stability of the cementless (BFX) acetabular cup. BFX cups were implanted into foam blocks reamed to resemble acetabulae with simulated 0, 25, 50, and 75% DAR loss. Models were tested in edge loading of the lateral surface of ...

STUDY DESIGN Retrospective review of prospectively collected data. OBJECTIVE To assess the value of the deformity angular ratio (DAR, maximum Cobb measurement divided by number of vertebrae involved) in evaluating the severity of spinal deformity, and predicting the risk of neurologic deficit in posterior vertebral column resection (PVCR). SUMMARY OF BACKGROUND DATA Although the literature ...

The proteins of simian virus 40 (SV40) and two human papovaviruses, the hemagglutinating BK virus and the non-hemagglutinating DAR virus, were analyzed and compared by sodium dodecyl sulfate polyacrylamide gel electrophoresis. The virions of SV40 and DAR contain seven proteins. By molecular weight analysis the constituent proteins of SV40 and DAR are identical. Approximately 84% of the viral pr...

Uterine leiomyomata (UL), the most common neoplasm in reproductive-age women, are classified into distinct genetic subgroups based on recurrent chromosome abnormalities. To develop a molecular signature of UL with t(12;14)(q14-q15;q23-q24), we took advantage of the multiple UL arising as independent clonal lesions within a single uterus. We compared genome-wide expression levels of t(12;14) UL ...

background: uterine leiomyoma (ul) is a benign tumor of uterine smooth muscle that affects women in reproductive ages. fas has an important role in initial stages of apoptosis. previous studies have shown an association between the fas gene and tumorigenesis. in the present study, we evaluated the relationship between fas a-670g (rs 1800682) and ul risk. methods: the fas gene polymorphism of 15...

The emergence of free/open source software-FS/OSS-enterprises seeks to push software development out of the academic stream into the commercial mainstream, and as a result, end-user applications such as open source database management systems (PostgreSQL, MySQL, Firebird) are becoming more popular. Companies like Sybase, Oracle, Sun, IBM are increasingly implementing open source strategies and ...

There is a need for a brief specific measure of anger for use in assessment of posttraumatic mental health problems. One unpublished short scale is the Dimensions of Anger Reactions (DAR; R. Novaco, 1975). This study examined the psychometric properties of the DAR using intake and 12-month data for 192 Australian Vietnam veterans with combat-related PTSD. Results showed the DAR to be unidimensi...

The D2 dopamine receptor (D2 DAR) is one of the most validated drug targets for neuropsychiatric and endocrine disorders. However, clinically approved drugs targeting D2 DAR display poor selectivity between the D2 and other receptors, especially the D3 DAR. This lack of selectivity may lead to undesirable side effects. Here we describe the chemical and pharmacological characterization of a nove...