Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...

introduction: the use of lopinavir/ritonavir (lpv/r) has decreased morbidity and mortality due to human immunodeficiency virus (hiv); however its use could be impaired by hepatotoxicity. therefore, this study was designed to investigate the effects of melatonin (mt) and alpha lipoic acid (ala) on lpv/r-induced hepatotoxicity in male albino rats. methods: rats were divided into groups and treate...

introduction: this study evaluated the effects of pretreatments with melatonin (mt), and alpha lipoic acid (ala) on lopinavir/ritonavir (lpv/r) -induced serum levels of creatinine (cr), urea (u), uric acid (ua) and kidney levels of malondialdehyde (mda), superoxide dismutase (sod), glutathione (gsh) and catalase (cat) in male albino rats. effects of treatments with mt and ala were also evaluate...

Aquatic organisms present, not only simple sources of accumulated metal, but can interact with metals, altering their toxicity. Due to exposition of biosphere with metals, organisms have developed various defense mechanisms to protect themselves against adverse effects of these ions and their compounds. Metallothionein (MT) is one of that which represents a critical mechanism for detoxification...

There are several independent sets of findings concerning the neural basis of reading. One set demonstrates a powerful relationship between phonological processing and reading skills. Another set reveals a relationship between visual responses in the motion pathways and reading skills. It is widely assumed that these two findings are unrelated. We tested the hypothesis that phonological awarene...