at present, when a clinical diagnosis of parkinson’s disease (pd) is made, serious damage has already been done to nerve cells of the substantia nigra pars compacta. the diagnosis of pd in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategies designed to slow or halt the progression of this disease that possibly prevents accumulation o...

seeds deterioration is a natural phenomenon that occurs in all seeds and leading to gradual decline of seed viability during storage. however, the rate at which seeds age depends upon their physiological status, genetic constitution and storage conditions. in the present study we the examined relationship between accumulation of reducing and non-reducing of sugars, soluble protein, the activity...

P- and E-selectins are expressed on the surface of endothelial cells and may contribute to neutrophil recruitment following injurious lengthening contractions of skeletal muscle. Blunting neutrophil, but not macrophage, accumulation after lengthening contractions may provide a therapeutic benefit as neutrophils exacerbate damage to muscle fibers, while macrophages promote repair. In this study,...

A general methodology for stochastic fatigue life prediction under variable amplitude loading is proposed in this paper. The methodology combines a nonlinear fatigue damage accumulation rule and a stochastic S–N curve representation technique to achieve this objective. The nonlinear damage accumulation rule proposed in this paper improves the deficiencies inherent in the linear damage accumulat...

In sheet metal forming processes with complex strain paths, a part is subjected to large plastic deformation. This severe plastic deformation leads to high plastic strain localization zones and subsequent accumulation of those strains. Then internal and superficial micro-defects and in other words ductile damage is created. This damage causes quality problems such as fracture. Therefore, design...