Objective(s): Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, the aim of this study was to investigate the effects of AS on HILI on premature rats and alveolar type II (AEC II) cells.Materials and Methods: Sprague-Dawley...

background: il-4 is a cytokine that induces differentiation of naive helper t cells into th2 cells. once activated by il-4, th2 cells subsequently produce additional il-4. objective: to examine the effect of il-4 on il-17 production and its effect in collagen- induced arthritis (cia) mice. method: in this study, a chicken collagen-ii-induced experimental arthritis (cia) model was used in dba/1 ...

Background: Mesenchymal stem cells (MSCs) possess a wide range of immunomodulatory functions mostly in immune cells including dendritic cells (DCs). DCs are the key cells in the immune response and play an important role in initiating cell-mediated immunity. Objective: To evaluate the immunomodulatory effects of MSCs supernatant on maturation and function of DCs. Methods: Bone marrow derived m...

background: correlation between diabetes mellitus (dm) and oral lichen planus (olp) seems probable. since interleukin‑8 (il‑8) is an important inflammatory mediator involved in both conditions, this study aimed to measure and compare the serum level of il‑8 in dm, olp, and dm + olp patients in comparison with healthy individuals. materials and methods: this cross sectional study was conducted o...

Background: Tegument protein pp150 of cytomegaloviruses (CMVs) plays a vital role in all stages of viral life cycle, representing the most important tegument protein candidate for HCMV treatment. However, the exact role of pp150 in immune regulation is yet to be elucidated. Objective: To examine the effects of pp150 on the maturity and function of muri...

background: mesenchymal stem cells (mscs) possess a wide range of immunomodulatory functions mostly in immune cells including dendritic cells (dcs). dcs are the key cells in the immune response and play an important role in initiating cell-mediated immunity. objective: to evaluate the immunomodulatory effects of mscs supernatant on maturation and function of dcs. methods: bone marrow derived mi...

Objective: The current study aimed to characterize the variation of serum PCT and IL-6 levels and look the specificity and the sensitivity in diagnosing pneumonia, urinary and superficial surgical site infections during the perioperative period of primary hip and knee arthroplasty. Methods: This observational study included 73 patients undergoing primary hip and knee arthroplasty. Serum Procalc...

We argue that M2 brane is realized as a topological soliton on a coincident pair of M5 and anti-M5 branes, as the two five-branes annihilate each other. Topology and quantum numbers of this world-volume soliton are discussed in some detail, and its formation is explained qualitatively. It follows from a compactification that a D4-antiD4 pair annihilate and produce type II fundamental strings. T...