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The Institute of Public Health of the Osijek-Baranja County has processed the data on cancer patients that were collected from mandatory county hospitals data reports, county bureaus of statistics and the County Register of Deaths. The cancers were defined according the International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10), codes of malignant n...

Background: MEN1309/OBT076 is an antibody drug conjugate (ADC) consisting of anti-CD205 monoclonal (moAb) conjugated to the DM4 maytansine derivative via a cleavable N-succinimidyl-4-(2-pyridyldithio) butanoate linker (Merlino et al, 2019), currently in phase 1 (NCT04064359). CD205 expression prevalent different tumor types, including hematological malignancies, where MEN1309 has potent vitro a...

DNA repair alkyltransferases protect organisms against the cytotoxic, mutagenic, and carcinogenic effects of alkylating agents by transferring alkyl adducts from DNA to an active cysteine on the protein, thereby restoring the native DNA structure. We used random sequence substitutions to gain structure-function information about the human O6-methylguanine–DNA methyltransferase (EC 2.1.1.63), as...

Scab, caused by Cladosporium cucumerinum Ell. et Arthur, is a prevalent disease of cucumber (Cucumis sativus L.) worldwide. Scab can cause serious losses for cucumber production, especially in protected culture such as high tunnel production. Resistance to cucumber scab is dominant and is controlled by a single gene, Ccu. Breeding for resistant cultivars is the most efficient way to control the...

The European XFEL is based on superconducting accelerator technology developed in the context of the TESLA collaboration [1]. The accelerator itself consists of cryo modules equipped with 8 cavities, followed by a quadrupole/steerer package, a BPM and a HOM absorber. This contribution will present the layout of the BPM system for the cryo modules, describing the monitor itself, its integration ...