A new class of water-soluble C60 transfecting agents has been prepared using Hirsch-Bingel chemistry and assessed for their ability to act as gene-delivery vectors in vitro. In an effort to elucidate the relationship between the hydrophobicity of the fullerene core, the hydrophilicity of the water-solubilizing groups, and the overall charge state of the C60 vectors in gene delivery and expressi...

We report the preparation and single-molecule observation of a high molecular weight C60-end-capped, stereoregular poly(methyl methacrylate) (PMMA-C60) with a precisely controlled structure. The highly isotactic PMMA-C60 (mm = 98%) with a narrow molecular weight distribution was synthesized by the stereospecific anionic living polymerization of tert-butyl methacrylate followed by end-capping wi...

Research on biological effects of C60 and its derivatives is one of the hotspots in the area of biological effects of nanomaterials. Compared with surface-modified C60 derivatives, reports on the biological effects of unmodified pristine C60 are relatively less. This work aimed to investigate the interaction between baby hamster kidney cells and pristine C60 in solution. The C60 suspension was ...

Fullerenes are widely produced and applied carbon nanomaterials that require a thorough investigation into their environmental hazards and risks. In this study, we compared the toxicity of pristine fullerene (C60) and carboxylated fullerene (C60-COOH) to white rot fungus Phanerochaete chrysosporium. The influence of fullerene on the weight increase, fibrous structure, ultrastructure, enzyme act...

Superconducting behavior even under harsh ambient conditions is expected to occur in La@C60 if it could be isolated from the primary metallofullerene soot when functionalized by CF3 radicals. We use ab initio density functional theory calculations to compare the stability and electronic structure of C60 and the La@C60 endohedral metallofullerene to their counterparts functionalized by CF3. We f...

Single crystals of three-dimensional (3D) C60 polymer were prepared by the topotactic conversion of two-dimensional (2D) C60 polymer single crystals at a pressure of 15 GPa at 600 degrees C. The x-ray single crystal study revealed that the 3D C60 polymer crystallized in a body centered orthorhombic space group Immm, and spherical C60 monomer units were substantially deformed to rectangular para...

The antitumor activity of pristine C60 fullerene aqueous solution (C60FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1.2-dimethylhydrazine (DMH) in rats. The number, size, and location of the tumors were measur...

BACKGROUND Clinacanthus nutans (Burm. f.) Lindau leaves are widely used by cancer patients and the leaf extracts possess cytotoxic and antiproliferative effects on several human cancer cell lines. However, the effect of C. nutans leaf extract on human melanoma, which is the least common but most fatal form of skin cancer and one of the most common cancers diagnosed in both sexes worldwide, is u...

The interaction of C60 with single-wall carbon nanotubes (SWNTs) and graphite is studied experimentally by thermal desorption spectroscopy and theoretically by molecular-mechanics and molecular-dynamics calculations. The van der Waals parameters and force field for C60-graphene and C60-SWNT interactions are derived from the low-coverage C60 binding energy to the graphite surface. We use these t...