glibenclamide (glib) is a poorly soluble drug with formulation-dependent bioavailability. therefore, we attempted in this study to improve glib dissolution rate by preparing drug solid dispersions by solvent evaporation (se) and supercritical fluid solvent-antisolvent techniques (scf-sas). a d-optimal mixture design was used to investigate the effects of different ratios of hpmc e5 (50-100%), p...

In this paper, a manipulability analysis of a new parallel-type rolling mill, named ‘‘paramill,’’ in its conceptual design stage is investigated. The paramill considered uses two Stewart platforms (SPs) in opposite directions for the generation of 6 degree-offreedom motions of individual work-rolls. The objective of this new approach is to pursue an integrated control of the strip thickness, st...