1. Amino acid metabolism and protein synthesis in a Staphylococcus aureus mutant strain that requires pyrithiamine for optimum growth were studied and compared with those in the thiamine-requiring parent S. aureus. 2. The mutant strain utilized amino acids at a higher rate than did the parent strain. The utilization of glutamic acid, serine and glycine was much stimulated in the mutant strain. ...

Immobilized cell reactor of the bacterium Corynebacterium glutamicum entrapped into carrageenan gel beads was constructed and used for the investigation of batch, fed-batch and continuous production of L-glutamic acid from nutritionally enriched sugarcane molasses. High final L-glutamic acid concentration (>93 g l ) was achieved, in batch fermentation, but with low productivity of 3.8 g l h . R...

Deoxynivalenol (DON) has various toxicological effects in humans and pigs that result from the ingestion of contaminated cereal products. This study was conducted to investigate the protective effects of dietary supplementation with glutamic acid on piglets challenged with DON. A total of 20 piglets weaned at 28 d of age were randomly assigned to receive 1 of 4 treatments (5 piglets/treatment):...

UNLABELLED D-Glutamate is an essential component of bacterial peptidoglycan and a building block of the poly-γ-D-glutamic acid (PDGA) capsule of Bacillus anthracis, the causative agent of anthrax. Earlier work suggested that two glutamate racemases, encoded by racE1 and racE2, are each essential for growth of B. anthracis, supplying D-glutamic acid for the synthesis of peptidoglycan and PDGA ca...

Proline is synthesized from glutamic acid by way of the intermediate glutamic -y-semialdehyde, as in the following equation: glutamic acid + glutamic 'y-semialdehyde -* proline. In Escherichia coli W, the first reaction is subject to endproduct inhibition by proline (A. Baich and D. J. Pierson, Biochim. Biophys. Acta 104:397, 1965). This reaction is also inhibited by low, although higher than b...