objective: biebersteinia (geraniaceae) has a history of use in traditional medicine in some countries including iran. in the present study, cytotoxic and apoptogenic properties of hydro-ethanol extract of b. multifidi was investigated on human prostate cancer cell lines (pc3 and du 145) and human embryonic kidney 293 (hek293) cells. materials and methods: cells were cultured in rpmi-1640 medium...

numerous studies have been focused on natural anticarcinogenic agents. many antioxidants have been identified as anticarcinogens. antimutagens have also been proposed as cancer chemopreventive agents. the use of natural products as anticancer has a long history that began with traditional medicine. the aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...

it has been reported that latex and extracts of different species of ficus are cytotoxic to some human cancerous cell lines. in this study, cytotoxicity of fruit and leaf extracts as well as the latex of ficus carica l. on hela cell line were evaluated. ethanolic extracts of leaves and fruits were prepared through percolation and ethyl acetate and dichloromethane extracts were prepared by reflu...

background: this study was performed to determine antifungal activity of silver nanoparticles (nano-ag) compared to voriconazole on clinical and standard strains of aspergillus fumigatus. materials and methods: inhibitory potency of nano-ag was determined using microtiter broth dilution method. susceptibility tests were performed against a. fumigatus isolated from bal (bronchoalveolar lavage) o...

current therapies for breast cancer are often limited by short-term efficacy due to the emergence of drug resistance. there has been increased interest in the use of naturally occurring compounds with chemopreventive and chemotherapeutic effects in the treatment of cancers. saffron, dry stigmas crocus sativus l., used in iran as a spice, is known for its anticancer properties. in this study, th...

Quercetin, a ubiquitous flavonol, represents a promising leading drug for development of new chemotherapeutic agents. However, its limited cytotoxicity to cancer cells hampers its clinical use. In order to obtain novel quercetin derivatives with superior cytotoxicity, seven alkylated quercetin derivatives were synthesized. Solubility of these derivatives was determined by turbidimetry. Cytotoxi...

malaria is a parasitic disease with limited chemotherapy options. chemotherapy options are limited; moreover, drug resistant frequently occurs. the speed of drug development should be faster to overcome the emerging drug resistance. in the current study, a series of quinolone derivatives were subjected to quantitative structure activity relationship to identify the ideal physicochemical charact...

calotropis gigantea (linn) and amoora rohituka (roxb.) have long been used in folkloric medicine for the treatment of various ailments in bangladesh. the present study was designed to investigate the cytotoxicity of isolated compounds from these two plants. two compounds, named β-boswellic acid (compound-1) and 2-methoxy-14-calamenenone (compound-2) were isolated from the flowers of calotropis ...