Cytoplasmic dynein is responsible for intra-cellular transport in eukaryotic cells. Using Fluctuating Finite Element Analysis (FFEA), a novel algorithm that represents proteins as continuum viscoelastic solids subject to thermal noise, we are building computational tools study the mechanics of these molecular machines. Here present methodology obtaining material parameters required represent fl...

Background: Mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. Antineutrophil Cytoplasmic Antibodies (ANCA's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculitic sy...

Background: The use of conventional stains including Giemsa, Wright and Leishman have become an essential tool for differential diagnosis of cells in peripheral blood. Aims: The aim of the study was to develop a new combination of Leishman-Giemsa (L&G;) stain for avian blood smears and to compare its efficacy with conventional staining methods. Methods:<...

Examination of antinuclear antibody (ANA) is used in diagnosis systemic autoimmune diseases, and the indirect immunofluorescence (IIF) assay using HEp-2 cells gold standard method. allows detection multiple target antigen-directed autoantibodies. The guide “The International Consensus on ANA Patterns (ICAP)”, characterizes patterns into three groups: nuclear, cytoplasmic, mitotic. majority thes...

antineutrophil cytoplasmic autoanibodies (anca) were detecte in patients with certain autoimmune vascular disease such as wegner’s granulomatosis, polyarthrits nodosa and systemic luuc erythematous. indirect immunofluorescence (iif) technique was employed to detec these autoantibodies.anca have been recently detected in some forms of inflammatory bowel disease (ibd), ulcerative colitis (u.c). c...

Introduction: HER2/neu, a member of the epidermal growth factor receptor family, has been shown to be over-expressed in some tumors. The purpose of this study was to determine the salivary levels and tissue expression of HER2/neu in patients with head and neck squamous cell carcinoma (HNSCC) and their correlation with clinicopathologic parameters.   Materials and Methods: Enzyme-linked immu...

Background: Polyunsaturated fatty acids (PUFAs) have been shown to influence fertility and endocrinology of reproduction and metabolic activity in many species. In dairy cows, we and others have shown changes in steroid and metabolic hormones and prostaglandins leading to alteration of ovarian activity and uterine function. These can influence fertility by changes in folliculogenesis cyclicity ...

background: metastasis and recurrence of colorectal cancer after treatment is attributed to stem cells. the aim of this study was to determine the relationship between the expression of stem cell marker cd166 in colorectal cancer by immunohistochemistry and clinicopathologic parameters.methods: from 2006 to 2012, 121 colectomy specimens of patients with colon cancer that were operated in babol ...