نتایج جستجو برای: cytogenetic risk groups
تعداد نتایج: 1591243 فیلتر نتایج به سال:
BACKGROUND Cytogenetic abnormalities have been described in a few patients with otherwise typical severe aplastic anemia (SAA), and the possible clonal nature of this disease is a controversial issue. MATERIALS AND METHODS Sixty-nine patients with acquired severe aplastic anemia underwent cytogenetic examination on bone marrow cells at the time of diagnosis (n = 34) and/or at least twice afte...
BACKGROUND The impact of cytogenetic abnormalities in multiple myeloma after allogeneic stem cell transplantation has not been clearly defined. This study examines whether allogeneic stem cell transplantation could be of benefit for myeloma patients with high-risk cytogenetic abnormalities. DESIGN AND METHODS This is a retrospective multicenter analysis of the registry of the Société Français...
Since the first precise definition of myelodysplastic syndromes (MDS) in 1982, prognostication of this disease has been a matter of debate. It very quickly became clear that the prognosis of MDS patients cannot be assessed by a single parameter, although the prognostic impact of the FAB classification, which is based on bone marrow morphology, is still impressive. This reflects the fact that th...
ObjectiveTo test the hypothesis that telomere shortening and/or loss are risk factors for infertility.DesignRetrospective analysis of status in patients with infertility using conventional cytogenetic data collected prospectively.SettingAcademic centers.Patient(s)Cytogenetic slides cultured peripheral lymphocytes from 50 undergoing fertility treatment and 150 healthy donors, including 100 donor...
abstract: about 60% of total premium of insurance industry is pertained?to life policies in the world; while the life insurance total premium in iran is less than 6% of total premium in insurance industry in 2008 (sigma, no 3/2009). among the reasons that discourage the life insurance industry is the problem of adverse selection. adverse selection theory describes a situation where the inf...
Lenalidomide is a novel thalidomide analogue with enhanced immunomodulatory and antiangiogenic action lacking most of the typical thalidomide-associated adverse events. In myelodysplastic syndromes (MDS), it has been used primarily in the IPSS low- and intermediate-1 risk setting. Several trials have demonstrated its potential to lead to both erythroid and cytogenetic responses in these disease...
AIM Evaluation of chromosomal radiosensitivity of healthy individuals and determination those with the increased susceptibility to radiogenic cancer. METHODS Cytogenetic examination of radiation induced injuries in lymphocytes of healthy individuals (n=103) was carried out on the basis of G(2)-assay. Test system of peripheral blood lymphocytes with metaphase analysis was used. RESULTS On th...
The reliability of genome analysis and proficiency of genetic manipulation requires knowledge of the correspondence between the genetic and cytogenetic maps. In the present study, we integrated cytogenetic and microsatellite-based linkage maps for Zhikong scallop, Chlamys farreri. Thirty-eight marker-anchored BAC clones standing for the 19 linkage groups were used to be FISH probes. Of 38 BAC c...
BACKGROUND Neuroblastoma (NB) is the most common extracranial solid tumour of childhood. Several genomic imbalances correlate to prognosis in NB, with structural rearrangements, including gene amplification, in a near-diploid setting typically signifying high-risk tumours and numerical changes in a near-triploid setting signifying low-risk tumours. Little is known about the temporal sequence in...
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