نتایج جستجو برای: cystatin c

تعداد نتایج: 1057234  

Journal: :Clinical chemistry 2000
B Stabuc L Vrhovec M Stabuc-Silih T E Cizej

BACKGROUND Serum cystatin C, a cysteine protease inhibitor, has been suggested as a new marker of glomerular filtration rate (GFR). This study explored the possibility of replacing the creatinine clearance (CrCl) estimation of GFR with cystatin C in early detection of renal impairment in cancer patients on chemotherapy. METHODS Serum creatinine and cystatin C concentrations as well as 24-h Cr...

Journal: :The Journal of biological chemistry 2013
Hanna Wallin Magnus Abrahamson Ulf Ekström

To elucidate the molecular requirements for cancer cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of the protein were produced and used for uptake experiments in MCF-7 cells. Variants with alterations in the cysteine cathepsin binding region ((Δ1-10)-, K5A-, R8G-, (R8G,L9G,V10G)-, (R8G,L9G,V10G,W106G)-, and W106G-cystatin C) were internalized to a ...

2016
Sander W. van der Laan Tove Fall Aicha Soumaré Alexander Teumer Sanaz Sedaghat Jens Baumert Delilah Zabaneh Jessica van Setten Ivana Isgum Tessel E. Galesloot Johannes Arpegård Philippe Amouyel Stella Trompet Melanie Waldenberger Marcus Dörr Patrik K. Magnusson Vilmantas Giedraitis Anders Larsson Andrew P. Morris Janine F. Felix Alanna C. Morrison Nora Franceschini Joshua C. Bis Maryam Kavousi Christopher O’Donnell Fotios Drenos Vinicius Tragante Patricia B. Munroe Rainer Malik Martin Dichgans Bradford B. Worrall Jeanette Erdmann Christopher P. Nelson Nilesh J. Samani Heribert Schunkert Jonathan Marchini Riyaz S. Patel Aroon D. Hingorani Lars Lind Nancy L. Pedersen Jacqueline de Graaf Lambertus A.L.M. Kiemeney Sebastian E. Baumeister Oscar H. Franco Albert Hofman André G. Uitterlinden Wolfgang Koenig Christa Meisinger Annette Peters Barbara Thorand J. Wouter Jukema Bjørn Odvar Eriksen Ingrid Toft Tom Wilsgaard N. Charlotte Onland-Moret Yvonne T. van der Schouw Stéphanie Debette Meena Kumari Per Svensson Pim van der Harst Mika Kivimaki Brendan J. Keating Naveed Sattar Abbas Dehghan Alex P. Reiner Erik Ingelsson Hester M. den Ruijter Paul I.W. de Bakker Gerard Pasterkamp Johan Ärnlöv Michael V. Holmes Folkert W. Asselbergs

BACKGROUND Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. OBJECTIVES The aim of this study was to use Mendelian randomization to in...

Journal: :International journal of clinical and experimental pathology 2015
Yan Yan Kun Zhou Liping Wang Yue Zhou Xinfeng Chen Qingxia Fan

OBJECTIVE To investigate the expression of cystatin C gene and its effect on the proliferation, apoptosis and invasiveness of EC9706 cells in esophageal carcinoma. METHODS 56 cases of esophageal carcinoma were randomly collected from our hospital. Samples of human esophageal carcinomas and matched normal esophageal mucosal epithelium were selected by resection operation from these patients. E...

Journal: :Clinical chemistry 2000
A W Butch

;25% false negatives. By contrast, plasma cystatin C better reflected GFR with the strongest correlation with Cr-labeled EDTA clearance and no false negatives. In a group of adult transplant recipients at steady-state renal function (average time since transplantation, 6 years), cystatin C was shown to have a better diagnostic value than serum creatinine for a GFR cutoff set at 60 mL/min (3 ). ...

2018
Ayu Ogawa-Akiyama Hitoshi Sugiyama Masashi Kitagawa Keiko Tanaka Akifumi Onishi Toshio Yamanari Hiroshi Morinaga Haruhito Adam Uchida Kazufumi Nakamura Hiroshi Ito Jun Wada

Cystatin C is a cysteine protease inhibitor that is produced by nearly all human cells. The serum level of cystatin C is a stronger predictor of the renal outcome and the risk of cardiovascular events than the creatinine level. The resistive index (RI) on renal Doppler ultrasonography is a good indicator of vascular resistance as well as the renal outcomes in patients with chronic kidney diseas...

Journal: :Frontiers in bioscience : a journal and virtual library 2008
Atsushi Nagai Masaharu Terashima Abdullah Md Sheikh Yoshitomo Notsu Koichi Shimode Shuhei Yamaguchi Shotai Kobayashi Seung U Kim Junichi Masuda

Cystatin C Leu68Gln variant is known to induce amyloid deposition in cerebral arterioles, resulting in Icelandic type cerebral amyloid angiopathy (CAA). Wild-type cystatin C is also observed in solitary CAA involving amyloid beta protein (Abeta), and accelerates the amyloidogenicity of Abeta in vitro. In neurological inflammatory diseases and leptomeningeal metastasis, low cystatin C levels are...

Journal: :Blood cells, molecules & diseases 2010
Ioannis Papassotiriou Alexandra Margeli Eugenia Hantzi Polyxeni Delaporta Athanassia Sergounioti Evgenios Goussetis Vassilios Ladis Antonis Kattamis

Deferasirox (Exjade) is a once-daily, oral iron chelator approved for the treatment of transfusional iron overload. This study was conducted to analyze changes in cystatin C concentration, an endogenous marker of glomerular filtration rate (GFR), in patients with thalassemia receiving daily deferasirox therapy over a period of at least 9 months. One hundred and fifty beta-thalassemia patients w...

Journal: :Clinical science 2002
Wolfgang Domej Gernot Peter Tilz Zeno Földes-Papp Ulrike Demel Thomas Rabold Herwig Holzer

There has been considerable recent interest in the potential use of serum cystatin C as a diagnostic tool. Here we examined the hypothesis that the cystatin C level in the pleural effusion can differ from the corresponding serum level. We evacuated pleural effusion fluids from 47 patients by thoracentesis. Cystatin C, beta(2)-microglobulin, inorganic phosphate, creatinine and total protein were...

2017
Danny Jensen Casper Kierulf-Lassen Marie Louise Vindvad Kristensen Rikke Nørregaard Kathrin Weyer Rikke Nielsen Erik Ilsø Christensen Henrik Birn

BACKGROUND Cystatin C, a marker of kidney injury, is freely filtered in the glomeruli and reabsorbed by the proximal tubules. Megalin and cubilin are endocytic receptors essential for reabsorption of most filtered proteins. This study examines the role of these receptors for the uptake and excretion of cystatin C and explores the effect of renal ischemia/reperfusion injury on renal cystatin C u...

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