The title compound, C26H26N2·0.5C8H10, is the first reported characterized 2:2 product from acid-catalyzed condensation of indole with cyclo-penta-none and no other 2:2 products were observed. Recrystallization from p-xylene gave the title hemisolvate with the p-xylene mol-ecule located about an inversion center. The terminal penta-lene ring is envelope-flap disordered at the C atom farthest fr...

The title compound, C(26)H(27)NO(4)S, with a thiophene ring fused to a quinoline ring, was synthesized via the condensation of dihydro-thio-phen-3(2H)-one 1,1-dioxide, 5,5-dimethyl-3-(phenyl-amino)cyclo-hex-2-enone and 3-methoxy-benzaldehyde in refluxing ethanol. In the crystal structure, the thiophene dioxide ring and the pyridine ring adopt envelope conformations. The connection of the pyridi...

Bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. They were synthesized by different methods. Herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using Sulfonic acid functionalized silica (SiO2-Pr-SO3H) in aqueous media is reported. The advantages of this new metho...

Bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. They were synthesized by different methods. Herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using Sulfonic acid functionalized silica (SiO2-Pr-SO3H) in aqueous media is reported. The advantages of this new metho...

Abstract Under different concentrations of the base potassium deuteroxide KOD, progress reactions, such as enolization, D‐substitution, isomerization, and conformational changes diketopiperazine cyclo(L‐Pro‐L‐Xxx) cyclo(D‐Pro‐L‐Xxx) (Xxx = Phe, Tyr) in D 2 O solution, was investigated by 1 H nuclear magnetic resonance (NMR). Cyclo(L‐Pro‐L‐Xxx) is mostly isomerized to whereas only slightly even ...

Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported one-pot multi component cyclo-condensation of an alkayane urea / Thiourea Aldehyde to 2- amino-4H-1, 3-Oxazines or Different catalysts like Trifluoro-acetic acid, glacial acetic acid under reflux condition Mandal Co-workers have utilized perchloric (HClO4) supported on silica gel as c...

The addition of an aqueous solution diketopiperazine cyclo(Pro-Xxx) (Xxx: amino acid residue) to (?)-epigallocatechin-3-O-gallate (EGCg) led precipitation the complex EGCg and cyclo(Pro-Xxx). molecular capture abilities using were evaluated by ratio amount included in precipitates with that total used. Stronger hydrophobicity side chain residue a higher ability. Furthermore, ability decreased w...

ABSTRACT : Dihydropyrimidines (DHPMs) are of much importance due to excellent pharmacological properties. In this account we have synthesized new functionalized DHPMs (a) 5-benzoyl-6-methyl-4-phenyl-3,4dihydropyrimidin-2(1H)-one (KT-01) and (b) 5-benzoyl-4-(4-chlorophenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one (KT-03) in two step reaction. The first step involves the synthesis of benzoylaceto...

The side product of the cyclo-condensation reaction between ethyl benzimidazole-2-carboxyl-ate and the nitrile imine of the corresponding hydrazonyl chloride, C20H11BrClN5O, crystallized in two crystal forms. Form (1) is a co-crystal of the target compound (without any chlorine substituent) and a side product containing a Cl atom in position 2 of the bromo-phenyl group, C20H12BrN5O·0.143C20H11B...

The title compound, [Cu(2)(C(31)H(30)Cl(2)N(4)O(4))Cl(2)]·CH(3)CN, was synthesized by cyclo-condensation between N,N'-bis-(2-fur-yl)-N,N'-bis-(3-formyl-5-chloro-salicylaldehyde)ethyl-enediamine and 1,3-diamino-propane in the presence of Cu(II) ions. It is an unsymmetrical dinuclear Cu(II) complex. The coordination geometry for each Cu(II) atom can be discribed as distorted square-pyramidal. The...