A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.

Eukaryotic cyclic nucleotide-modulated (CNM) ion channels perform various physiological roles by opening in response to cyclic nucleotides binding to a specialized cyclic nucleotide-binding domain. Despite progress in structure-function analysis, the conformational rearrangements underlying the gating of these channels are still unknown. Here, we image ligand-induced conformational changes in s...

The activation of a cyclic nucleotide-gated channel is the final step in sensory transduction in olfaction. Normally, this channel is opened by the intracellular cyclic nucleotide second messenger cAMP or cGMP. However, in single channel recordings we found that donors of nitric oxide, a putative intercellular messenger, could directly activate the native olfactory neuron channel. Its action wa...

Substrate activation by means of a reactive ligand is a topic of much interest. Herein we describe a stoichiometric anti-Markovnikov C-N bond formation involving ligand reactivity in multiple steps along the reaction coordinate, including ligand assisted substrate (de)protonation and C-N bond formation, as illustrated by a combined experimental, spectroscopic and computational study. This affor...

A new macrocyclic ligand (H2L) was synthesized by reaction of Acenaphthoquinone and oaminophenol. Then, its Co (II), Ni (II), Cu (II), Zn (II) and Cd (II) complexes were synthesized by the condensation method. Macrocyclic ligand (H2L) and Co(NO3)2.6H2O, Ni(NO3)2.6H2O, Cu(NO3)2.6H2O, ZnCl2.2H2O and CdCl2.2H2O respectively. The ligand and its complexes have been characterized by IR, H, UV–Vis spe...

A series of ligands that contain both N-donor and N-oxide donor atoms have been synthesised and ligands L5, L6, L7 and L8 contain, 4, 6, 5, and 6 donor atoms respectively. The smallest ligand L5 forms a mononuclear complex with Cu2+ ([Cu(L5)(ClO4)2(MeCN)]) whereas L6 and L7 form dinuclear double helicates with Ni2+ and Cu2+ respectively ([Ni2(L6)2]4+ and [Cu2(L7)2]4+). L8 forms a tetranuclear c...

Reacting nickel(ii)perchlorate with a bidentate P,N-ligand in methanol leads to P,C-bond cleavage and gives a five-coordinate nickel complex wherein the nickel(ii) site is coordinated by a tridentate P,N,P-ligand and a bidentate N,C-ligand. The carbanion of the latter is the result of the P,C-bond cleaving process. The diamagnetic nickel(ii) complex was characterized by means of elemental analy...

The synthesis, molecular and electronic structures, redox properties of pyrazine(diimine) (PzDI) metal dihalide complexes (DiPPPZDI)MX2 (DiPP = 2,6-diisopropylphenyl; M Mn, Fe, Co, Ni; X Cl, Br) are presented compared. reduced to (DiPPPZDI)MX monohalide complexes, the role ligand non-innocence in structure compounds is examined compared related pyridine(diimine) (PDI) compounds. were characteri...