We report further characterization of the physical and immunologic properties, mechanism of action, and intracellular localization of Acanthamoeba castellanii capping protein, an actin regulatory protein discovered by Isenberg (Isenberg, G., U. Aebi, and T. D. Pollard, 1980, Nature (Lond.) 288:455-459). The native molecular weight calculated from measurements of Stokes' radius (3.8 nm by gel fi...

objective: bioactive glass is often used as a filler material for repair of dental bone defects. in different studies osteogenic potential of this material was proved, but its dentinogenesis property is in doubt. the purpose of this study was to evaluate the histological pulp responses of calcium hydroxide and bioactive glass placed directly on exposed pulp tissues. materials and methods: twent...

DESCRIPTION A healthy 18-year-old male patient came for a routine dental examination. His medical history was uneventful. Mandibular left central incisors exhibited small prominent cusp on its lingual surface (figure 1). The cusp was teatlike, projected from the cement–enamel junction and extended halfway to the incisal edge. The cusp measured 4.5 mm in length (incisocervically), 3.5 mm in widt...

Bursts of actin polymerization in vivo involve the transient appearance of free barbed ends. To determine how rapidly barbed ends might appear and how long they might remain free in vivo, we studied the kinetics of capping protein, the major barbed end capper, binding to barbed ends in vitro. First, the off-rate constant for capping protein leaving a barbed end is slow, predicting a half-life f...

Left coronary cusp perforation is an extremely rare consequence of blunt chest trauma. A 22-year-old male presented after a motor vehicle accident with dyspnea. Transthoracic echocardiogram (TTE) and transesophageal echocardiogram (TEE) showed moderate to severe aortic regurgitation with prolapsing right coronary cusp. In the operating room he was found to have a left coronary cusp tear near th...

Talon cusp is a dental anomaly also known as an eagle's talon. It is an extra cusp on an anterior tooth which arises as a result of evagination on the surface of a crown before calcification has occurred. The exact etiology is unknown. The inci-dence of talon cusp is less than 6%. Commonly involved teeth are maxillary incisors, usually unilateral but in some instanc-es bilateral. The classical ...

Dens evaginatus is a developmental anomaly that is observed as additional tuberculate cusp on the palatal surface of incisor teeth (talon cusp) or the occlusal surface of molar teeth. This additional cusp consists of enamel, dentin, and usually pulp. A 9-year-old boy presented with a talon cusp on the palatal surface of maxillary left lateral incisor. The clinical and radiographic appearance an...

OBJECTIVE Patients with supracoronary ascending aortic aneurysms can have aortic insufficiency (AI) due to dilatation of the sinotubular junction and/or associated cusp pathology. The incidence and types of cusp lesions as well as the effect of AI severity and cusp repair techniques on outcome in this patient population is not well defined. METHODS Since 1996, 55 patients (mean age: 65 ± 13 y...

A talon cusp is a dental anomaly commonly occurring in the permanent dentition compared to the primary dentition. It commonly affects the maxillary anterior teeth. In primary dentition, the most commonly affected tooth is the maxillary central incisors. This is a rare case report of a 5-year-old male patient with a talon cusp affecting the mandibular primary lateral incisor. Recognition and tre...