Introduction: Pheochromocytoma is an exceptional cause of Cushings syndrome. We report the very case a composite pheochromocytoma-ganglioneuroma with ectopic secretion adrenocorticotrophic hormone, two rare histological entities grouped into one, in patient complex clinical feature. Case Report: This 62-year-old consulting for polyarthralgia and low back pain whom physical examination found The...

Cushing’s syndrome is associated with serious morbidity and increased mortality. Irrespective of its cause, i.e. a pituitary adenoma, ectopic ACTH production or an adrenal neoplasia, Cushing’s syndrome is primarily treated surgically. However, when surgery is unsuccessful or contraindicated, medical therapy is needed to treat hypercortisolism. The spectrum of available drugs includes adrenal-bl...

Dopamine (DA) is a catecholamine with a wide range of functions and whose five subtype receptors are found in different organs where they exert a mainly inhibitory action. Since this action may also appear in a number of secretory tumors in various locations, DA agonists have elicited some interest as a medical treatment for hypercorticism. Non-iatrogenic Cushing’s syndromes are due in 70% of t...

In the laboratory rat and guinea pig, glucocorticoids (GCs), the adrenal steroids that are secreted during stress, can damage the hippocampus and exacerbate the hippocampal damage induced by various neurological insults. An open question is whether GCs have similar deleterious effects in the primate hippocampus. In fact, we showed that sustained and fatal stress was associated with preferential...

There are grossly four elements to help control faecal continence: 1. Plug function Internal anal sphincter (IAS) plays a major role in acting as a plug at the final end of our gastrointestinal tract. It is innervated by our autonomous nervous system. External anal sphincter (EAS), puborectalis sling plus other pelvic floor muscle and haemorrhoidal cushings at anal canal also contribute. 2. Sto...

OBJECTIVE : To assess the prevalence of PCOS among infertile women according to Rotterdam criteria. STUDY DESIGN : Cross Sectional Study PLACE AND DURATION OF STUDY: Baqai Institute of Reproduction and developmental Sciences (BIRDS) from Jan 2009 – Dec 2009 MATHODOLOGY: 1210 participants included in the study, were those who came in BIRDS OPD for fertility concerned. Detailed history, examinati...