HYPOTHESIS Only selected patients require steroid replacement therapy following adrenalectomy. DESIGN Retrospective review. SETTINGS University tertiary care center and veterans' hospital. PATIENTS A total of 331 patients who underwent adrenalectomy by 1 surgeon (Q.-Y.D.) between April 1, 1993, and August 31, 2005. INTERVENTIONS Laparoscopic, open, and hand-assisted adrenalectomy. Stero...

Münchhausen’s syndrome (MS) is a chronic factitious disorder characterized by the intentional production of clinical symptoms without external incentive. One type of MS is factitious Cushing syndrome, an extremely rare clinical situation in which the diagnosis is challenging mainly due to interference of the exogenous medication in cortisol immunoassays. We described a 26-year-old woman who was...

In 1932 Harvey Cushing described a number of patients presenting a similar clinical picture which he had collected from the literature, and he added two more from his own records. The presence of minute adenomata of basophil cells in the anterior lobe of the pituitary gland was demonstrated at autopsy on some of them and Cushing regarded these as the causative lesions and called the syndrome 'p...

Arq Bras Endocrinol Metab 2007;51/8 Celebration of the 75th Anniversary of Cushing’s Syndrome IT IS OPPORTUNE THAT THIS ESPECIAL issue of the Brazilian Journal of Endocrinology and Metabolism comes out just in time to celebrate the 75th anniversary of the original description of the disease that turned out to be known as Cushing’s syndrome. Harvey Williams Cushing (April 8, 1869 — October 7, 19...

Münchhausen's syndrome (MS) is a chronic factitious disorder characterized by the intentional production of clinical symptoms without external incentive. One type of MS is factitious Cushing syndrome, an extremely rare clinical situation in which the diagnosis is challenging mainly due to interference of the exogenous medication in cortisol immunoassays. We described a 26-year-old woman who was...

Massive thoracoabdominal aortic thrombosis is a rare finding in patients with iatrogenic Cushing syndrome in the absence of any coagulation abnormality. It frequently represents an urgent surgical situation. We report the case of an 82-year-old woman with massive aortic thrombosis secondary to iatrogenic Cushing syndrome. A follow-up computed tomography scan showed a decreased amount of thrombu...

In spite of the presence of definitive diagnostic criteria to diagnose Cushing syndrome diagnosis may become challenging. We report a young female with mild clinical features of Cushing syndrome, who had nonsuppressible oral dexamethasone suppression tests; also she had a suspicious pituitary lesion. She underwent pituitary surgery and a pituitary microadenoma (non-ACTH staining) was removed. N...

Cushing syndrome is rare in infancy and usually due to an adrenocortical tumor (ACT). We report an infant with Cushing syndrome due to adrenocortical carcinoma. The patient presented at six months of age with a three-month history of growth failure, rapid weight gain, acne, and irritability. Physical examination showed obesity, hypertension, and Cushingoid features. Biochemical evaluation showe...

A 48-year-old woman was incidentally found to have bilateral adrenal masses, 2.8 cm in diameter on the right, and 2.3 cm and 1.7 cm in diameter on the left, by abdominal computed tomography. The patient had a medical history of hypertension, which was not being controlled by carvedilol, at a dose of 25 mg daily. She presented with signs and symptoms that suggested Cushing Syndrome. We diagnosed...