Prolonged use of topical corticosteroids, particularly in infants, albeit rare, may lead to Cushing syndrome. Central nervous system abnormalities including brain atrophy and delayed myelination on cranial magnetic resonance imaging has been reported in patients with corticosteroid treatment. We herein report a 5-month-old female infant referred to Department of Pediatric Endocrinology, Edirne,...

Ritonavir is commonly used in low doses to boost plasma levels of protease inhibitors in patients with human immunodeficiency virus (HIV) infections. It is also a potent inhibitor of cytochrome P450. We present a 50-year-old African American male with past medical history of HIV on highly active antiretroviral therapy (HAART), which also included ritonavir and long standing asthma that has been...

N early a century ago, Karl Germain (1878-1956), a magician who had an international reputation for conjuring, became blind from a brain tumor. It ended his career. His physicians in Cleveland, Ohio, advised him to consult the eminent neurosurgeon Harvey Cushing, MD (1869-1939), in Boston, Massachusetts. Cushing successfully removed the tumor and reported the case in his landmark article on men...

368 If you are going for it, I certainly would go in for it hard. Halfway measures never got anybody anywhere. – Letter from Harvey Cushing to his son Bill regarding his son's intention to join the Yale varsity hockey team. O n a Saturday morning in 1926, Dr Harvey Cushing, chief and professor of surgery at Harvard's Peter Bent Brigham Hospital, operated meticulously on a young woman with a bra...

To those who were fortunate enough to be present at the seventieth birthday party held for Dr. Cushing by the Harvey Cushing Society in New Haven, April 8, 1939, this little book will remain a precious and cherished memento; to those friends and former pupils of Dr. Cushing not there for that gay and happy occasion it will be an especially coveted treasure-a last visit with "the Chief"; and to ...

OBJECTIVE To report a meta-analysis of late-night salivary cortisol testing for the diagnosis of Cushing syndrome. METHODS MEDLINE and EMBASE computer databases were searched to identify relevant articles published between January 1950 and December 2007. The search strategy used the following medical subject headings and keywords: cortisol, Cushing or Cushing's, saliva, salivary, late-night, ...

El objetivo de este trabajo fue resaltar la importancia del diagnóstico causa síndrome Cushing, en un paciente canino macho, 12 años edad, con carcinoma cortical adrenal, que llega a consulta por presentar signos clínicos compatibles Síndrome Cushing. Los resultados estimulación ACTH sintética (Synacthen 0.25 mg®) arrojaron aumento el cortisol basal (10.8 µg/dl) y pos-estimulación (28.4 µg/dl)....

Massive thoracoabdominal aortic thrombosis is a rare finding in patients with iatrogenic Cushing syndrome in the absence of any coagulation abnormality. It frequently represents an urgent surgical situation. We report the case of an 82-year-old woman with massive aortic thrombosis secondary to iatrogenic Cushing syndrome. A follow-up computed tomography scan showed a decreased amount of thrombu...