Histological slides from the lungs of 89 dead asbestos cement workers have been examined with respect to ferruginous bodies and fibrosis. The results have been compared with individually matched controls with no known exposure to asbestos, and related to asbestos exposure, expressed as duration of exposure and cumulative asbestos dose, and smoking habits. The asbestos cement workers studied had...

OBJECTIVE To determine the incidence of withdrawal syndrome after prolonged infusion of fentanyl and midazolam in children, and the associated risk factors. DESIGN Historic or retrospective cohort study. SETTING Pediatric Intensive Care Unit in an academic center. PATIENTS Forty-eight pediatric patients who received sedation and analgesia only with fentanyl and midazolam through continuou...

The relationship between external dose and internal dose of trichloroethylene (Tri) was analyzed by using a physiological simulation model. The external dose of Tri was represented by the time-weighted average (TWA) concentration in inhaled air or by the product of exposure concentration and exposure duration, and the internal dose by the area under the curve (AUC) of Tri blood concentration or...

ABSTRACT. This paper provides an elementary introduction into modeling of localized inelastic processes such as cracking or formation of shear bands. The basic concepts are explained using a simple one-dimensional example. It is shown that a stress-strain law with softening used in a standard continuum description leads to physically meaningless results and that the numerical solution suffers b...

I estimate rates for cumulative particle production from C, Ca and Pb nuclei for conditions of Fermilab experiment E665 of p-A deep inelastic scattering. Estimates have been obtained on the basis of hadron-nuclei interactions experimental data. The possibility of also detecting backward produced charged particles by liquid scintillator neutron counters is discussed. This experiment, to be run i...

BACKGROUND This study aimed to determine the association between different weight histories, including cumulative excess weight, cumulative excess waist circumference (WC), duration of general and central adiposity, current and maximum body mass index, and current and maximum WC, and incident coronary heart disease (CHD) and stroke. METHODS AND RESULTS The study population consisted of 4398 a...

OBJECTIVES To construct a cohort-specific job-exposure matrix (JEM) using surrogate metrics of exposure for a cancer study on career firefighters from the Chicago, Philadelphia and San Francisco Fire Departments. METHODS Departmental work history records, along with data on historical annual fire-runs and hours, were collected from 1950 to 2009 and coded into separate databases. These data we...