The role of neuroendocrine peptide calcitonin (CT) and its receptor (CTR) in epithelial cancer progression is an emerging concept with great clinical potential. Expression of CT and CTR is frequently elevated in prostate cancers (PCs) and activation of CT-CTR axis in non-invasive PC cells induces an invasive phenotype. Here we show by yeast-two hybrid screens that CTR associates with the tight ...

We report the measurement of electron-beam microbunching at the exit of a self-amplified spontaneous-emission free-electron laser (SASE FEL), by observation of coherent transition radiation (CTR). The CTR was found to have an angular spectrum much narrower than spontaneous transition radiation and a narrow-band frequency spectrum. The central frequency of the fundamental CTR spectrum is found t...

Counter-mode encryption (“CTR mode”) was introduced by Diffie and Hellman already in 1979 [5] and is already standardized by, for example, [1, Section 6.4]. It is indeed one of the best known modes that are not standardized in [10]. We suggest that NIST, in standardizing AES modes of operation, should include CTR-mode encryption as one possibility for the next reasons. First, CTR mode has signi...

High levels of calcitonin (CT) observed in medullary thyroid carcinoma and other CT-secreting tumours cause severe diarrhoea. Previous studies have suggested that CT induces active chloride secretion. However, the involvement of CT receptor (CTR) and the molecular mechanisms underlying the modulation of intestinal electrolyte secreting intestinal epithelial cells have not been investigated. The...

Yale Cardiovascular Rsrch Ctr, Section of Cardiovascular Medicine, Dept of Internal Medicine; Dept of Genetics; Dept of Surgery; Biostatistics Resource, Keck Laboratory; Dept of Pharmacology; Dept of Pathology; Vascular Biology and Therapeutics Program, Yale Univ Sch of Medicine; Dept of Biostatistics, Yale Sch of Public Health; Yale Stem Cell Ctr, New Haven, CT; Dept of Cell Biology, Univ of C...

The calcitonin receptor (CTR) is relevant to three hormonal systems: amylin, calcitonin, and calcitonin gene-related peptide (CGRP). Receptors for amylin and calcitonin are targets for treating obesity, diabetes, and bone disorders. CGRP receptors represent a target for pain and migraine. Amylin receptors (AMY) are a heterodimer formed by the coexpression of CTR with receptor activity-modifying...

The present study aimed to investigate the association between cardiothoracic ratio (CTR) and left ventricular (LV) systolic function parameters in patients with or without preserved LV ejection fraction (LVEF). A total of 203 subjects suspected with coronary artery disease underwent chest radiography and dual source computed tomography coronary angiography (DSCT-CA). The LV systolic function p...