Cav1.2 Ca(2+) channel activity diminishes in inside-out patches (run-down). Previously, we have found that with ATP, calpastatin domain L (CSL) and calmodulin (CaM) recover channel activity from the run-down in guinea pig cardiac myocytes. Because the potency of the CSL repriming effect was smaller than that of CaM, we hypothesized that CSL might act as a partial agonist of CaM in the channel-r...

Human learners can resolve referential ambiguity and discover the relationships between words and meanings through a cross-situational learning (CSL) strategy. Some people with aphasia (PWA) can learn word-referent pairings under referential uncertainty supported by online feedback. However, it remains unknown whether PWA can learn new words cross-situationally and if such learning ability is s...

We present CCMC (Conditional CSL Model Checker), a model checker for continuous-time Markov chains (CTMCs) with respect to properties specified in continuous-time stochastic logic (CSL). Existing CTMC model checkers such as PRISM or MRMC handle only binary CSL until path formulas. CCMC is the first tool that supports algorithms for analyzing multiple until path formulas. Moreover, CCMC supports...

Regulation of transcription is fundamental to development and physiology, and occurs through binding of transcription factors to specific DNA sequences in the genome. CSL (CBF1/Suppressor of Hairless/LAG-1), a core component of the Notch signaling pathway, is one such transcription factor that acts in concert with co-activators or co-repressors to control the activity of associated target genes...

Continuous Spontaneous Localization (CSL) is one possible explanation for dynamically induced collapse of the wave-function during a quantum measurement. The collapse is mediated by a stochastic non-linear modification of the Schrödinger equation. A consequence of the CSL mechanism is an extremely tiny violation of energy-momentum conservation, which can, in principle, be detected in the labora...

The Notch/CSL pathway plays an important role in skin homeostasis and carcinogenesis. CSL, the key effector of canonical Notch signaling endowed with an intrinsic transcription repressive function, suppresses stromal fibroblast senescence and Cancer Associated Fibroblast (CAF) activation through direct down-modulation of key effector genes. Interacting proteins that participate with CSL in this...

Abstract. We combine the notion of norming algebra introduced by Pop, Sinclair and Smith with a result of Pisier to show that if A1 and A2 are operator algebras, then any bounded epimorphism of A1 onto A2 is completely bounded provided that A2 contains a norming C ∗-subalgebra. We use this result to give some insights into Kadison’s Similarity Problem: we show that every faithful bounded homomo...

CSL [CBF-1, Su(H), Lag-1]-type transcription factors are the primary effectors of the Notch pathway, a signal transduction cascade that is essential for the development of all metazoan organisms. Interestingly, CSL proteins were originally classified as transcriptional repressors in vertebrates, but as transcriptional activators in model invertebrate organisms. Resolution of this paradox came w...

Many cancer cells over-express significantly the glycoproteins specific to the endogenous cerebellar soluble lectin or CSL. These ligands may present the same electrophoretic profiles regardless of the specie or tissue. We purified a large amount of the active CSL using an immuno-affinity chromatography, which was used to isolate the CSL ligands from human tumour K562 cell lines. After protease...

The generation and recognition of body language is a key technologies of VR. Sign Language is a visual-gestural language mainly used by hearing-impaired people. In this paper, gesture and facial expression models are created using computer graphics and used to synthesize Chinese Sign Language (CSL), and from it a human-computer CSL interaction system is implemented. Using a system combining CSL...