Glioblastomas (GBM) are paradigmatic for the investigation of cancer stem cells (CSC) in solid tumors. Recently, the discovery of CD133- CSC in addition to CD133+ CSC has substantially added to our understanding of the complexity of GBM CSC. This review gives an overview on our current knowledge on CD133- cells in GBM and describes five different hypothesizes on the nature of CD133- cells in GB...

Involvement of cancer stem cells (CSC) in initiation, progression, relapse, and therapy-resistance of colorectal cancer (CRC) warrants search for small molecules as 'adjunct-therapy' to target both colon CSC and bulk tumor population. Herein, we assessed the potential of silibinin to eradicate colon CSC together with associated molecular mechanisms. In studies examining how silibinin modulates ...

In recent years cancer stem cells (CSCs) have been hypothesized to comprise only a minor subpopulation in solid tumors that drives tumor initiation, progression, and metastasis; the so-called "cancer stem cell hypothesis." While a seemingly trivial statement about numbers, much is put at stake. If true, the conclusions of many studies of cancer cell populations could be challenged, as the bulk ...

Continuous service certification (CSC) recently emerged as a promising means to provide ongoing assurances and disrupt pertinent approaches. CSC involves the consistent gathering assessing of certification-relevant data by authorities about operation validate adherence criteria. While research on is increasing, practitioners still struggle in transferring researchers' suggestions guidelines int...

Human mesenchymal stromal/stem cells (MSC) isolated from fetal tissues hold promise for use in tissue engineering applications and cell-based therapies, but their collection is restricted ethically and technically. In contrast, the placenta is a potential source of readily-obtainable stem cells throughout pregnancy. In fetal tissues, early gestational stem cells are known to have advantageous c...

In the dawn of 6G era, evolving service ecosystems raise need for cross-service interactions. Existing resource/service orchestration frameworks are oblivious to such interactions, since they tend orchestrate services independent each other. this respect, we stress on optimized crossservice communication, and more specifically, cross-slice communication (CSC). To end, present a CSC platform, na...