Library organizations in the Netherlands show an increasing interest to employ depots for low-cost storage and demand fulfillment of item requests. Typically, all libraries organization have a shared catalog, and, on local unavailability, requests can be shipped from elsewhere organization. The depot used consolidate shipment by making tours along libraries, delivering requested items, but also...

The system of distribution of goods and services, along with other economic developments around the world, is rapidly evolving. In the world of distribution of goods, the main focus is on making distribution operations more effective. Due to the fact that the cross-dock has the advantage of removing intermediaries and reducing the space required for the warehouse, it is worth considering. Among...

Automated docking of drug-like molecules into receptors is an essential tool in structure-based drug design. While modeling receptor flexibility is important for correctly predicting ligand binding, it still remains challenging. This work focuses on an approach in which receptor flexibility is modeled by explicitly specifying a set of receptor side-chains a-priori. The challenges of this approa...

Docking, the initial association of secretory vesicles with the plasma membrane, precedes formation of the SNARE complex, which drives membrane fusion. For many years, the molecular identity of the docked state, and especially the vesicular docking protein, has been unknown, as has the link to SNARE complex assembly. Here, using adrenal chromaffin cells, we identify the vesicular docking partne...

Integrating Dock-Door Assignment and Vehicle Routing in Cross-Docking

The necessity of treating receptor flexibility in proteinligand docking has been widely acknowledged and is the subject of extensive research in the field of drug discovery [1]. The use of multiple discrete protein conformations, so-called ensemble docking, has been proven to be a valid concept to mimic target plasticity in docking experiments [2,3]. Using molecular dynamics (MD) the number of ...

Multi-echelon distribution networks are quite common in supply chain and logistics. Deliveries of multiple items from factories to customers aremanagedby routing and consolidating shipments inwarehouses carrying on long-term inventories. On the other hand, cross-docking is a logistics technique that differs from warehousing because products are no longer stored at intermediate depots. Instead, ...

One of the most important factors in implementing supply chain management is to efficiently control the physical flow of the supply chain. Due to its importance, many companies are trying to develop efficient methods to increase customer satisfaction and reduce costs. In various methods, cross-docking is considered a good method to reduce inventory and improve responsiveness to various customer...