We examined some of the metabolic events that regulate sensitizing cancer extract-induced leukocyte adherence inhibition and found that human leukocytes adhere in a comparatively passive manner to glass in serum-free medium. Adherence of leukocytes to glass did not require oxidative metabolism, microtubules, microfilaments, or calcium entry, whereas leukocyte mobility excited by sensitizing can...

The effectiveness of cromolyn sodium versus placebo for the prophylaxis of aqthmatic symptoms was studied by using a double-blind-crossover clinical trial in 20 patients with symptomatic asthma. Eleven patients showed significant improvement in maximum voluntary ventilation, dyspnea index, and maximum mid-expiratory flow rate. Asthma uncomplicated by chronic bronchial infection predominated in ...

Cromolyn explored diverse pharmacological effects including antioxidant, anti-inflammatory and anticancer properties. The cytotoxic or anti-cell proliferative potential of cromolyn has been well documented in various cancer cell lines. To date, there are no studies on the chemopreventive potential of cromolyn against 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinogenesis. The chemopr...

Stack, chimneylike, and threadlike assemblies have previously been proposed for the structure of disodium cromoglycate (DSCG) aggregates in aqueous solutions. The results of the synchrotron x-ray scattering investigations reported here reveal the formation of simple columnar assemblies with π-π stacking at a separation of 3.4 Å between the DSCG molecules. Lateral separation between the assembli...

BACKGROUND We previously found that S100P, a member of the S100 protein family, is expressed in more than 90% of pancreatic tumors and is associated with tumor growth and invasion. In the current study, we investigated the ability of the antiallergy drug, cromolyn, to block S100P function. METHODS Interactions between cromolyn and S100P were investigated using a drug affinity column and by ex...