© 2009 by the American College of Gastroenterology The American Journal of GASTROENTEROLOGY INTRODUCTION Crohn ’ s disease (CD) encompasses a multisystem group of disorders with speci c clinical and pathological features characterized by focal, asymmetric, transmural, and, occasionally, granulomatous in ammation primarily a ecting the gastrointestinal (GI) tract. $ is multisystem disorder with ...

Simultaneous turnover studies with radioiodine-labelled IgM and IgG were made in 12 patients with Crohn's disease. Intestinal protein loss was estimated by means of 59Fe-labelled iron dextran. The serum levels of IgM, IgG, and IgA were normal in most cases. The catabolic rate of IgM was increased in all but one case. A positive correlation was present between the catabolic rate and serum concen...

While surgical resection remains a mainstay of the treatment of Crohn’s disease (CD), postoperative recurrence of disease is common. The ideal management of patients after surgery is unclear and varies widely in clinical practice. Both patients and clinicians must weigh the risks and benefits of treatment in reaching a decision. Those at low risk of postoperative recurrence may not need any the...

Crohn’s disease is characterized by chronic intestinal inflammation and not rarely by extraintestinal manifestations. Psoas abscess and fistula is a rare complication of Crohn’s disease, which is sometimes difficult to diagnose in the early stage. We describe the case of a 22-year-old male patient with Crohn’s disease who presented to us with difficulty in walking and pain in the area of the ri...

Crohn’s disease is a chronic inflammatory condition that can affect any segment of the gastrointestinal tract from the oral cavity to the anus. The disease often manifests with varied symptoms and numerous potential complications that include intestinal strictures, enteric fistulas, intaabdominal abscesses, and gastrointestinal hemorrhage. Patients with Crohn’s disease are a heterogeneous group...

background: in some studies inflammatory bowel disease (ibd) and celiac disease were considered to be associated and some belive that this association may influence the prognosis of ibd. however, there is a cosiderable controversy regarding this association. therefore ,we aimed to assess the association of these two common digestive diseases and evaluate the complications of this association. m...

Colitis-associated colorectal cancer (CAC) seems to be a rather unique entity and differs in its genetic alterations, tumour formation capacities, and clinical features from sporadic colorectal carcinoma. Most descriptions about tumour biology of CAC refer to ulcerative colitis; data about Crohn´s colitis related carcinomas are scarce. The majority of patients with Crohn´s disease are under imm...