Introduction: Morphine is a potent analgesic but its continual use results in analgesic tolerance. Mechanisms of this tolerance remain to be clarified. However, changes in the functions of μ-opioid and N-Methyl-D-aspartate (NMDA) receptors have been proposed in morphine tolerance. We examined changes in gene expression of the NMDA receptor subunit 1 (NR1) at mRNA levels i...

The striatum consists of GABAergic projection neurons and various types of interneurons. Despite their relative scarcity, these interneurons play a key role in information processing in the striatum. One such class of interneurons is the cholinergic tonically active neurons (TANs). In the dorsal striatum, TANs are traditionally considered to be responsive to events of motivational significance....

The cover image is based on the Research Article DARPP-32 cells and neuropil define striosomal system isolated matrix in human striatum by Christine Arasaratnam et al., https://doi.org/10.1002/cne.25488

The aim of this study was to determine the prevalence of helminthes eggs in dog feces collected in public areas in Pelotas, RS, Brazil. From January to March of 2012, 15 samples were randomly collected from each of 14 locations in this county. A total of 210 samples were submitted to fecal examinations. The overall prevalence was 57.6%, including both single (67.8%) and multiinfections (32.2%)....