INTRODUCTION Acute kidney injury (AKI) diagnosis is based on an increase in plasma creatinine, which is a slowly changing surrogate of decreased glomerular filtration rate. We investigated whether serial creatinine clearance, a direct measure of the glomerular filtration rate, provided more timely and accurate information on renal function than serial plasma creatinine in critically ill patient...

INTRODUCTION To compare the conventional creatinine clearance measured on 24-h urine collection with the estimated Glomerular Filtration Rate by Cockcroft & Gault (CG) and Modification of Diet in Renal Disease (MDRD) prediction equations in adults aged 20 years and above in Pakistani population. METHODS All the patients, including inpatient admitted in hospital and outpatients, more than 20 y...

1. The endogenous creatinine/GFR (inulin or free [s7Co]cyanocobalamin or ['Z51]iothalamate) clearance ratios were determined in ninety-nine non-nephrotic patients and subjects and in sixteen nephrotic patients. The clearance ratios of the nephrotic patients were not significantly different from those of the non-nephrotic patients and normal subjects. 2. The clearance ratios increased as the GFR...

BACKGROUND The use of endogenous plasma creatinine levels and creatinine clearance as a tool to evaluate renal function in mice has come under scrutiny as prior studies have reported that the Jaffé alkaline picrate method grossly overestimates true plasma creatinine in mice. As members of the NIDDK Animal Models of Diabetic Complications Consortium (AMDCC), we evaluated the performance and feas...

Amin A. Nanji, Division of Clinical Chemistry, Vancouver General Hospital, Vancouver V5Z1M9 (Canada) Dear Sir, Analytical and biologic variations in serum and urinary creatinine may account for up to 33% variability in creatinine clearance calculations [1]. We wish to report on the marked variability of creatinine clearance in patients receiving total parenteral nutrition (TPN). 18 of 93 patien...

The dose dependence of mezlocillin pharmacokinetics was examined in relation to renal function after intravenous doses of 1 and 5 g in 16 subjects with various degrees of renal impairment. Dose and time-average model-independent physiological parameters were calculated from plasma concentration and urinary excretion data. Lack of superimposition of plasma concentration profiles occurred between...