Objective: To investigate the effect of hyperbaric oxygen intervention on chronic wound healing in type 2 diabetes mellitus, and its influence on serum inflammatory factors, oxidative stress factors and angiogenesis related factors. Methods: Totally 78 type 2 diabetes mellitus patients with chronic wounds treated in our hospital were randomly divided into 2 groups, 39 cases in each group. The c...

Methotrexate (MTX) is a commonly used disease modifying antirheumatic drug (DMARD) for the treatment of RA because of its affordability, long-term efficacy and acceptable toxicity profile. MTX is also frequently used in the treatment of other forms of inflammatory arthritis. Although MTX is considered to be a well-tolerated DMARD, there is a significant inter-patient variability in the toxicity...

Management of acute pancreatitis (AP) is tailored by its severity, which is defined at 48 hr by the revised Atlanta or determinant-based classification. However, using these classifications, it is probably too late to offer any treatment that might change natural course of AP. The best markers for ruling out severe AP within the first day are APACHE II score. Marker that can rule-out pancreatic...

Twenty healthy 6-month-old male and female New Zealand rabbits with a mean body weight of 3.5±0.5 kg were fed a standard commercial rabbit diet and provided with water ad libitum containing 40 mg F/L for 70 days. Blood samples were obtained from each rabbit, and sera adenosine deaminase (ADA) activity and Creactive protein (CRP) and ceruloplasmin (CP) levels were determined with the following r...

An 8-year-old girl presented with left ankle pain and limping for 1 month. There was no history of trauma or febrile illness. Her medical history was unremarkable, and there was no family history of rheumatism. Physical examination revealed mild soft tissue swelling and tenderness over the lateral aspect of the ankle and heel. No skin change, local warmth or focal mass was evident, but the rang...

A 55-year-old white male presents for cardiology consultation to discuss options for reducing his cardiovascular risk (Fig. 1). He has a family history of ischemic heart disease—his father underwent coronary bypass surgery at age 70—and no other cardiac risk factors. Fasting lab results, which were obtained by his primary care physician, show a normal lipid profi le, but his high sensitivity Cr...

Methods The changes in sepsis markers (procalcitonin, presepsin, interleukin-6, Creactive protein) followed by IVIg administration were investigated in severe sepsis or septic shock patients. The subjects were 410 patients admitted to an ICU with a diagnosis of severe sepsis or septic shock and from whom informed consent had been obtained for the present study. IVIg was administered intravenous...

A 52-year-old man was admitted to our hospital because of headache and a sudden loss of right-sided vision. He had been diagnosed with central diabetes insipidus (CDI) four months before admission and had been treated with desmopressin. On admission, a magnetic resonance imaging (MRI) scan revealed sphenoidal sinusitis, inflammatory lesions in the right orbital apex, and hypophysitis (Picture a...

A ging is associated with increased inflammatory activity (1,2). Serum Creactive protein (CRP) is a sensitive marker of systemic low-grade inflammation and is an important predictor of type 2 diabetes (3,4) and cardiovascular disease (CVD) (5). Cross-sectional studies have found associations of CRP with metabolic syndrome (6–9) and its components, including obesity (10), insulin resistance (6,7...