Human infection by Coxiella burnetii, a zoonosis, is associated with the development of autoantibodies, though the clinical significance of these is unclear. We describe two patients with high-titer Q fever antibodies associated with autoimmune hepatitis (AIH) as demonstrated on biopsy and supported by autoantibody results. For one, the chronology of serologic results uniquely demonstrates the ...

We thank Dr Giles Youngs and Dr Peter Stride for highlighting a factual error in an article on Brucella and Coxiella (Clin Med 2015;15:91–2). The authors confi rm that the statement ‘Coxiella burnetii is the cause of Q fever, a term fi rst used in 1983 during the investigation of a cluster of febrile Australian meat workers’ should in fact read, ‘Coxiella burnetii is the cause of Q fever, a ter...

A seroepidemiologic survey of Coxiella burnetii in cattle and chickens in Thailand was carried out using indirect fluorescent antibody test. Nine of the 130 serum samples from cattle were positive for antibodies against C. burnetii, with antibody titers ranging from 32 to 64. Only one of 113 serum samples from chickens was seropositive, with antibody titer of 16. No C. burnetii-specific DNA was...

Coxiella burnetii is an intracellular bacterial pathogen and a significant cause of culture-negative endocarditis in the United States. Upon infection, the nascent Coxiella phagosome fuses with the host endocytic pathway to form a large lysosome-like vacuole called the parasitophorous vacuole (PV). The PV membrane is rich in sterols, and drugs perturbing host cell cholesterol homeostasis inhibi...

We investigated the role of the western grey kangaroo (Macropus fuliginosus) in the maintenance and transmission of Coxiella burnetii in Western Australia. Sera from 1,017 kangaroos were tested using an indirect enzyme-linked immunosorbent assay (ELISA) for the presence of C. burnetii antibodies. The overall antibody prevalence across 12 locations throughout mid- to southwestern Western Austral...

Chronic Coxiella burnetii endocarditis usually develops in people with underlying heart disease and accounts for 60-70% of chronic Q fever. Onset is generally insidious and manifestations are atypical. The authors report a case of Coxiella burnetii prosthetic valve endocarditis in a 53 years- old patient with recurrent mechanical valve dehiscence on mitral position. He lived in a rural area wit...

background: q fever is a zoonotic disease caused bycoxiella burnetii, a species of bacteria that is distributedworldwide. in cattle, coxiella burnetii infections are generallyasymptomatic but can also be associated with reproductivedisorders. objectives: the aim of this study was to achievemolecular detection of coxiella burnetii in dairy bovine milkfarms using nested pcr in qom province, iran....

BACKGROUND Coxiella burnetii, the causative agent of Q fever, may cause culture-negative vascular graft infections. Very few cases of C. burnetii infection of a vascular graft have been reported. All were diagnosed by serology. CASE PRESENTATION We report the first case of Coxiella burnetii vascular graft infection diagnosed by broad-range PCR and discuss the diagnostic approaches and treatme...

Diagnosis of ongoing or past infection with Coxiella burnetii, the causative agent of Q fever, relies heavily on serology: the measurement of C. burnetii-specific antibodies, reflecting the host's humoral immune response. However, cell-mediated immune responses play an important, probably even more relevant, role in infections caused by the intracellular C. burnetii bacterium. Recent studies ha...

Methods for the extraction of PCR-quality DNA from environmental soil samples by using pairs of commercially available kits were evaluated. Coxiella burnetii DNA was detected in spiked soil samples at <1,000 genome equivalents per gram of soil and in 12 (16.4%) of 73 environmental soil samples.