As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of anew group of 1,4-dihydropyridine (DHP) derivatives were presented. Novel synthesized compounds possessing a COX-2 SO2Me pharmacophore at the para position of C-4 phenyl ring, different hydrophobic groups (R1) at C-2 position and alkoxycarbonyl groups (...

A new series of peptide-like derivatives containing different aromatic amino acids andpossessing pharmacophores of COX-2 inhibitors as SO2Me or N3 attached to the para positionof an end phenyl ring was synthesized for evaluation as selective cyclooxygenase-2 (COX-2)inhibitors. The synthetic reactions were based on the solid phase peptide synthesis methodusing Wang resin. One of the analogues, i...

A very general mechanism for penalized regression has been added to the coxph function in S Plus A user written S Plus function can be supplied that gives addi tional term s to the partial likelihood along with the rst and second derivatives of those terms The variance and degrees of freedom for the extended model are then computed as outlined in Gray Several other arguments control optional as...

In all sorts of regression problems it has become more and more important to deal with high dimensional data with lots of potentially influential covariates. A possible solution is to apply estimation methods that aim at the detection of the relevant effect structure by using penalization methods. In this work, the effect structure in the Cox frailty model, which is the most widely used model t...

as a continuous research for discovery of new cox-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of anew group of 1,4-dihydropyridine (dhp) derivatives were presented. novel synthesized compounds possessing a cox-2 so2me pharmacophore at the para position of c-4 phenyl ring, different hydrophobic groups (r1) at c-2 position and alkoxycarbonyl groups (...

background: the aim of this study is to evaluate the association between different treatments and survival time of breast cancer patients using either standard cox model or stratified cox model. methods: the study was conducted on 15830 women diagnosed with breast cancer in british columbia, canada.  they were divided into eight groups according to patients’ ages and stage of disease either cox...