نتایج جستجو برای: cox 2 inhibitory

تعداد نتایج: 2641865  

Journal: :Molecules 2008
Xiang Li Zhi Liu Xin-feng Zhang Li-juan Wang Yi-nan Zheng Chang-chun Yuan Guang-zhi Sun

A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (...

Nonsteroidal anti-inflammatory drugs (NSAIDs) act mainly via inhibition of prostaglandins synthesis by inhibition of cyclooxygenase (COX) isoenzymes (COX1 and COX 2). Selective COX-2 inhibitors which are also known as coxibs provide the main therapeutic effects of NSAIDs. Zarghi et al. reported 6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid (AZGH 101) as a novel derivative of...

Journal: :Journal of natural products 1998
T Ringbom L Segura Y Noreen P Perera L Bohlin

A hexane extract of Plantago major was investigated by bioactivity-directed fractionation, using an in vitro cyclooxygenase-2 (COX-2) catalyzed prostaglandin biosynthesis inhibition assay, and resulted in the isolation of ursolic acid (1). This triterpenoid showed a significant COX-2 inhibitory effect, directly on the enzyme activity, with an IC50 value of 130 microM and a COX-2/COX-1 selectivi...

Journal: :International journal of molecular medicine 2014
Hua Hong Byeong-Churl Jang

Hearing loss can be induced by multiple causes, including cochlear inflammation. Prednisone (PDN) is a well-known steroid clinically used in the treatment of hearing loss. In the present study, we investigated the inhibitory effects and the mechanisms of action of PDN on the expression of cyclooxygenase (COX)-2, an inflammatory enzyme involved in the production of prostaglandins (PGs), in House...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Shahar Lev-Ari Ludmila Strier Diana Kazanov Liora Madar-Shapiro Hadas Dvory-Sobol Ilya Pinchuk Brigitte Marian Dov Lichtenberg Nadir Arber

PURPOSE Multiple studies have indicated that cyclooxygenase-2 (COX-2) inhibitors may prevent colon cancer, which is one of the leading causes of cancer death in the western world. Recent studies, however, showed that their long-term use may be limited due to cardiovascular toxicity. This study aims to investigate whether curcumin potentiates the growth inhibitory effect of celecoxib, a specific...

Journal: :Journal of Enzyme Inhibition and Medicinal Chemistry 2021

Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (Flu-AM4). The compound is competitive, reversible inhibitor of with Ki value 13 nM which inhibits COX activity in substrate-selective manner. Molecular modelli...

2014
Dayang Erna Zulaikha Awang Hamsin Roslida Abdul Hamid Latifah Saiful Yazan Che Norma Mat Taib Looi Ting Yeong

BACKGROUND In our previous studies conducted on Ardisia crispa roots, it was shown that Ardisia crispa root inhibited inflammation-induced angiogenesis in vivo. The present study was conducted to identify whether the anti-angiogenic properties of Ardisia crispa roots was partly due to either cyclooxygenase (COX) or/and lipoxygenase (LOX) activity inhibition in separate in vitro studies. METHO...

Journal: :middle east journal of digestive diseases 0
ashraf mohamadkhani mohammad reza akbari reza ghanbari elnaz naderi parisa rezanejad-asl akram pourshams

background there are hoarding documents for the biological importance of cyclooxygenase-2 (cox-2) in pancreatic carcinogenesis. we aimed to thoroughly investigate the dna sequence variations of whole cox-2 exons in a large case-control study of pancreatic cancer by direct sequencing.   methods the entire exonic regions of cox-2 including 10 exons were sequenced in the germline dna of 96 patient...

2014
Rekha Bisht S. Bhattacharya Yusuf Ali Jaliwala

The present study was aimed to evaluate the cyclooxygenase (COX) and lipoxygenase (LOX) inhibitory activity of Abroma augusta (AA) and Desmodium gangeticum (DG). Initially In-vivo anti-inflammatory activity of aqueous extract (AqE) of aerial parts of DG (100 mg/ml) and petroleum ether extract (PEE) of roots of AA (250 mg/ml) was assessed in carrageenan induced paw oedema model in albino wistar ...

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