arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. drug discovery and delivery to retard the degeneration of joint tissues are challenging. current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (nsaids) but ar...

The endometrium undergoes a dynamic proliferation of cells and vascular tissue under the influence ovarian steroid hormones. Implantation is an essential process in development pregnancy, where there close contact between embryo uterus, including supposition, adhesion, invasion. changes occur human endometrium, endometrial secretion changes, blood vessels, immune response, leading to uterine re...

Primary cultures of fetal hepatocytes expressed cyclooxygenase-2 (COX-2) upon stimulation with bacterial lipopolysaccharide (LPS) or peroxisomal proliferators. This enzyme was active and a good correlation between the mRNA levels, the amount of protein, and the synthesis of prostaglandin E2 was observed. However, when cells were incubated in the presence of indomethacin or the COX-2-specific in...

Introduction: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are used in treating pathologic conditions such as fever, pain and inflammation by inhibiting cyclooxygenase and consequently prostaglandin production. Recently , the discovery of different isoforms of this enzyme, Cyclooxygenase-1 (COX-1) and Cyclooxygense-2 (COX-2), has led to the synthesis and introduction of novel drugs with selec...

a substantial amount of evidence has proposed an important role for cyclooxygenase-2 (cox-2) enzyme in brain diseases and affiliate disorders. the purpose of this research was studying the effects of cox-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and parkinson’s disease (pd). in this study, the effect of acute and sub-chronic oral administration ...

The clycoxygenase (COX) enzyme forms locally active prostaglandins responsible for producing inflammation and pain. Classical non-steroidal anti-inflammatory drugs (NSAID) inhibit the COX-2 enzyme that produces inflammatory prostaglandins as well as the COX-1 enzyme that produces gastric mucosa protecting prostaglandins. By specifically inhibiting only the COX-2 enzyme, coxibs thus reduce pain ...

Cyclooxygenase-2 (COX-2) is involved in inhibition of apoptosis, potentiation of cell growth, and angiogenesis and as such is a target for drug development. The COX-2 enzyme is frequently overexpressed in pancreatic cancer. The aim of this study was to determine the effects of celecoxib on the growth inhibition and induction of apoptosis by gemcitabine in pancreatic cancer cell lines. Baseline ...

Inflammation reaction is a rapid process induced by prostaglandin E2 (PGE2) which is one of the yield products of cyclooxygenase (COX) enzyme. Mechanical trauma, corrosive chemicals and antigen-antibody reactions are the most common stimulants of inflammation reaction in the body. PGE2 affects the neurons resulting in systemic inflammation symptoms such as edema, pain and fever 1-2. Three diffe...

inhibition of prostaglandin (pgs) production leads to decrease in orthodontic tooth movement (otm). it is not known whether inhibition of cyclooxygenase-1 (cox-1) or cyclooxygenase-2 (cox-2) is the key mechanism for this effect. in this study, the effect of celecoxib, a highly-selective cox-2 inhibitor, was investigated on otm in rats.four groups of male rats (seven animals in each goup) were u...

Prostaglandins are important mediators of renal physiology and disease. The main enzyme which governs the synthesis of prostaglandins is cyclooxygenase (COX), also called prostaglandin endoperoxide synthase (PGS). Until recently it was assumed that only one cyclooxygenase gene and protein exists, an enzyme which is now called cyclooxygenase-l (COX-I) or the 'constitutive' isoform. Between 1989a...