PURPOSE To report the clinical features and investigate the underlying pathological processes of spontaneous corneal perforation in patients with ocular chronic graft-versus-host disease (cGVHD). METHODS A full ophthalmological evaluation of corneal perforation in four patients with cGVHD was performed. Three of them underwent deep anterior lamellar keratoplasty and samples from two of three ...

A 56-year-old woman had conductive keratoplasty (CK) for residual hyperopia and astigmatism. Three years before the procedure, the patient had arcuate keratotomy, followed by laser in situ keratomileusis 2 years later for high astigmatism correction in both eyes. During CK, a corneal perforation occurred in the right eye; during the postoperative examination, an iris perforation and anterior su...

PURPOSE To report an unusual presentation of pellucid marginal degeneration (PMD). CASE REPORT A 57-year-old man with history of corneal ectasia experienced acute hydrops and spontaneous corneal perforation in his right eye. Examination revealed PMD in both eyes. After initial treatment with cyanoacrylate adhesive and a bandage contact lens, therapeutic penetrating keratoplasty was undertaken...

CASE REPORT A 33-year-old Caucasian female presented with epiphora, ocular pain, and foreign body sensation in both eyes for one month. Examination revealed bilateral peripheral corneal ulcers. The patient had been treated with immunomodulators, and she was treated in the left eye with peripheral semi-circular keratoplasty, penetrating keratoplasty, conjunctival-corneal-scleroplasty, buccal muc...

PURPOSE To report a case of corneal perforation associated with oral administration of erlotinib and its spontaneous healing after temporary discontinuation of drug treatment. CASE REPORT A 65-year-old man with metastatic lung cancer was treated with erlotinib (150 mg/day), a specific tyrosine kinase inhibitor of the epidermal growth factor receptor. He was referred to our corneal service for...

BACKGROUND To report rapid corneal thinning and perforation in a case with relapsing polychondritis. CASE PRESENTATION A 43 year-old male diagnosed with relapsing polychondritis suffered from bilateral scleritis, bilateral swelling of pinna, saddle nose and tracheal stenosis. The patient presented with right eye pain and redness for one month. Slit lamp examination of the right eye showed 80%...

When established corneal ulcers induced by alkali burning were treated with 10% ascorbate drops, no perforation occurred, in contrast to a 25% incidence in the control group. If perforations and descemetoceles were grouped together, these difference became insignificant (i.e., 14.2% ascorbate-treated vs. 25% control). Prolongation of descemetocele presence without perforation in the ascorbate-t...

Chronic graft-versus-host disease (GVHD) is a common complication following allogeneic hematopoietic stem-cell transplantation (alloHSCT), frequently involving the ocular system. Topical or systemic use of corticosteroid is occasionally beneficial; however, there has been cases to progress to corneal perforation. We will report a case of a patient who developed corneal perforation in the course...

PURPOSE The purpose of this study is to report a case of corneal perforation in a patient with undiagnosed keratoconus and underlying rheumatoid arthritis. METHODS This is a retrospective case study based on the patient's medical records and followed by a brief review of the literature. RESULTS A 53-year-old patient was referred to our department for acute pain and sudden decrease of visual...

Deep anterior lamellar keratoplasty (DALK) is a promising technique for corneal transplantation that avoids the chronic immunosuppression comorbidities and graft rejection risk associated with penetrating keratoplasty (PKP), the standard procedure. In DALK, surgeons must insert a needle 90 % through the 500 μm cornea without penetrating its underlying membrane. This pushes surgeons to their man...