Based on an elementary osmotic pump, controlled release systems of diclofenac sodium (DS) were designed to deliver the drug in a zero-order release pattern. Osmotic pump tablets containing 100 mg DS were prepared and coated with either semipermeable (SPM) or microporous (PM) membranes. The tablet coats were composed of hydrophobic triacetin (TA) or hydrophilic polyethylene glycol 400 (PEG 400) ...

The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...

Abstract A 191, a Neo-Assyrian tablet from the Haus des Beschwörungspriesters in Aššur, preserves instructions for performance of an apotropaic ritual called Bīt mēseri (“house enclosure”). The tablet, which is edited here first time, offers version ceremony that markedly different standard known other first-millennium sources found at Nineveh, and various Babylonian sites. Whereas core rites w...

In majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovascular complications. Formulation of pulsatile system makes it possible to deliver drug at definite period of time when symptoms of the disease condition are most critical. The purpose of the present work was to develop pulsatile release tablet of losartan potassium for chronotherapy in hyp...

Cilnidipine, a novel calcium antagonist accompanied with Ltype and N-type calcium channel blocking function, is mainly used for treatment of hypertension. Due to its N-type calcium channel blocking properties, it has more advantages compared to conventional calcium channel blockers. The present investigation is aimed to formulate a pulsatile drug delivery system with a lag time of about 6 hr. C...

Objective: This study is to formulate Nebivolol into a Pulsatile liquid, solid composite compression coated tablet, which will delay the release of drug in early morning hypertension conditions. Methods: The tablet was formulated and compressed with ethylcellulose coating polymer. percent vitro liquid tested. Based on disintegration time wetting time, LCS2, LCS3, LSC6, LCS7 LCS12 formulations w...