This thesis focuses on the evaluation of growth factors, cytokines and chemokines present in the wound environment of burn, chronic and surgical wounds. The first chapters describe a differential expression of these mediators in wound exudates isolated from the 3 different wound types. Our results indicate that development of a universal therapy for these wounds is not an option. Since surgical...

introduction: spinal cord injury (sci) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. after severe spinal cord injury, astrocytes of the central nervous system (cns) become reactive astrocytes, and play the main role of glial scar formation. the scar is a major obstacle t...

Marjolin's ulcer is a rare and aggressive cutaneous malignancy that occurs in previously traumatized and chronically inflamed skin, especially after burns. The majority of burn scar carcinomas are seen after a lag period in burns that were not grafted following injury. Between 2000 and 2006, 48 patients with Marjolin's ulcer were treated in our centre (Sulaimani Teaching Hospital and Emergency ...

Reconstruction of the post-burn contracture is a complex task in plastic surgery. A burn patient treated traditionally only by dressings develops scar with contracture involving the burned region. The lip is a part of the face that is frequently affected by burn injury. Post-burn scar sequelae in this area often result in cosmetic disfigurement and psychological upset in patients. Microstomia p...

Restoration of form and function after burn injury remains challenging, but emerging laser and pulsed light technologies now offer hope for patients with hypertrophic scars, which may be associated with persistent hyperemia, chronic folliculitis, intense pruritis, and neuropathic pain. In addition to impairing body image, these scars may limit functional recovery, compromise activities of daily...

A neck scar contracture can severely and negatively affect the function of mastication, phonic, or breathing and result in neck pain and issues with esthetics. The best way is of course to avoid such contracture by means of non-surgical treatment such as use of a growth factor. The basic fibroblastic growth factor is clinically well proven in decreasing scar formation and improving healing. The...

It is important for clinicians to understand which are the clinical signs, the patient characteristics and the procedures that are related with the occurrence of hypertrophic burn scars in order to carry out a possible prognostic assessment. Providing clinicians with an easy-to- use tool for predicting the risk of pathological scars. A total of 703 patients with 2440 anatomical burn sites who w...

Introduction Orf disease is a viral disease of sheep and goats that can appear in humans too. The usual presentation is in sites that have direct contact. Clinical manifestation of Orf disease may be unusual in burn patients. Case Report In this case report, we described a rare presentation of Orf disease on a burn scar of a ...

Securing the airway is a crucial aspect during reconstructive surgeries of patients with extensive post-burn mentosternal scar contractures; however, the American Society of Anesthesiologists Difficult Airway Management Algorithm recommendation of initial direct laryngoscopy may not be appropriate for these complicated patients. Consequently, there is a significant risk for failure of intubatio...

In this paper we propose a method for the objective assessment of burn scars. The quantitative measures developed in this research provide an objective way to calculate scar elasticity. The approach combines range data and the mechanics and motion dynamics of human tissues. Active contours are employed to locate regions of interest and to find displacements of feature points using automatically...