This document is meant to complement Part B of the EANM 'Guidelines on current good radiopharmacy practice (cGRPP) in the preparation of radiopharmaceuticals' issued by the Radiopharmacy Committee of the European Association of Nuclear Medicine, covering small-scale in-house preparation of radiopharmaceuticals with automated modules. The aim is to provide more detailed and practice-oriented gui...

Radiopharmaceuticals for molecular imaging involve careful consideration of the following two factors: radionuclide selection and specificity to the molecular target. In selecting a radionuclide, the specific decay mode, physical half-life, chemical properties, and method of production must be considered. For proper design of a radiopharmaceutical which targets a specific biological or disease ...

Background Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these six 18F-labeled radiopharmaceuticals produced on a routine basis at the University of Pennsylvani...

During the years 1991–1997 the number of nuclear medicine (NM) laboratories and radionuclide investigations in Ukraine decreased significantly. The number of radioimmunoassays decreased by 2.2 times, functional radionuclide investigations fell by 4.6 times, scans and scintigraphies fell approximately by 10 times. The number of NM laboratories decreased from 81 in 1991 to 65 in 1998. Mainly this...

2-Mercapto-3-phenyl-4-quinazolinone complexes of copper is synthesized characterized on the basis of chemical properties, elemental data, magnetic susceptibility and characteristic absorption band in IR and ultra-violet absorption frequencies. The structure of complex underline the ability of Cu (I) centre to exist in distorted tetrahedral environment. The binding mode of the ligand is usual an...

background: owing to its favourable decay characteristics 177lu [t1/2= 6.71 d, eβ(max)= 497 kev] is an attractive radionuclide for various therapeutic applications. ethylene diamine tatramethylene phosphonate (edtmp) is one of the most widely used ligands which form stable complexes with various radionuclides and all the complexes. materials and methods: enriched 176lu2o3 was dissolved in 0.1 n...

Radiopharmaceuticals are radiation-emitting substances used in medicine for radiotherapy and imaging diagnosis. A Research Institute, located in Rio de Janeiro, produces three radiopharmaceuticals: the sodium iodate is used in the diagnosis of thyroid dysfunctions, the meta-iodo-benzylguanidine is used in the diagnosis of cardiac diseases, and the fluordesoxyglucose is used in diagnosis in card...

This review covers the side effects and adverse reactions to radiopharmaceuticals that were reported in the literature over the past 25 years. The information published prior to 1970 is sporadic, but due to the increased utilization of nuclear medicine procedures and the recognition that radiopharmaceuticals may have pharmacologic side effects, a registry has existed since 1971 to tabulate info...